Summary of results of multivariate regression between Monday morning and Monday afternoon and between Monday morning and Friday afternoon stratified by atopy: analysis with adjustment for age, gender and smoking status
| Parameter | Time | Non-atopic participants | Atopic participants | ||||
| Not exposed, mean (SD) | Exposed, mean (SD) | Mean difference in change between groups (95% CI) | Not exposed, mean (SD) | Exposed, mean (SD) | Mean difference in change between groups (95% CI) | ||
| Cytokines (pg/mL) | n=25 | n=8 | n=26 | n=8 | |||
| sCD40 | Monday morning | 2653 (1429) | 2839 (942) | 3618 (1704) | 4088 (2506) | ||
| Monday afternoon | 2266 (1469) | 5219 (2256) | 2529 (1080 to 3979) | 3302 (2381) | 4176 (2319) | 792 (−1550 to 3133) | |
| sCD62P | Monday morning | 4610 (2793) | 6647 (2643) | 5419 (3360) | 3942 (1727) | ||
| Monday afternoon | 4355 (2625) | 6183 (1979) | −104 (−1705 to 1497) | 4401 (2903) | 4725 (3168) | 1220 (−830 to 3269) | |
| sTNFR2 | Monday morning | 2538 (976) | 2558 (630) | 2945 (1227) | 3111 (1394) | ||
| Monday afternoon | 2380 (1069) | 3815 (1308) | 1562 (776 to 2348) | 2614 (1459) | 2950 (1611) | 587 (−860 to 2035) | |
| CRP (mg/L) | n=27 | n=10 | n=25 | n=8 | |||
| CRP median (IQR) and ratio* | Monday morning | 0.9 (0.5, 1.8) | 0.3 (0.2 to 0.7) | 0.6 (0.4 to 1.5) | 0.5 (0.3 to 1.7) | ||
| Monday afternoon | 0.7 (0.4 to 1.3) | 0.4 (0.2 to 1.0) | 1.3 (1.1 to 1.6) | 0.7 (0.4 to 1.8) | 0.6 (0.4 to 0.9) | 1.2 (0.9 to 1.4) | |
| Cytokines (pg/mL) | n=24 | n=11 | n=19 | n=12 | |||
| sCD40 | Monday morning | 2514 (1462) | 3067 (912) | 3535 (1741) | 4148 (2243) | ||
| Friday afternoon | 2292 (1624) | 4057 (1756) | 1995 (513 to 3477) | 1654 (2238) | 4660 (2565) | 2282 (411 to 4152) | |
| sCD62P | Monday morning | 4223 (2620) | 6865 (2568) | 5486 (3452) | 5105 (2562) | ||
| Friday afternoon | 5132 (3057) | 7722 (2799) | 2323 (178 to 4468) | 4760 (3041) | 5868 (4058) | 2487 (319 to 4654) | |
| sTNFR2 | Monday morning | 2571 (1018) | 2488 (617) | 2841 (1331) | 3204 (1282) | ||
| Friday afternoon | 2376 (1236) | 2561 (637) | 625 (−220 to 1470) | 2301 (877) | 3362 (1489) | 1351 (418 to 2283) | |
| CRP (mg/L) | n=24 | n=12 | n=18 | n=12 | |||
| CRP median (IQR) and ratio* | Monday morning | 1.1 (0.6 to 1.9) | 0.3 (0.2 to 0.6) | 0.6 (0.4 to 1.2) | 0.6 (0.3 to 2.0) | ||
| Friday afternoon | 0.8 (0.4 to 1.4) | 0.4 (0.2 to 0.8) | 1.0 (0.6 to 1.6) | 0.6 (0.3 to 1.8) | 0.6 (0.4 to 1.4) | 1.4 (0.9 to 2.3) | |
Note that numbers vary depending on the variable because not all of those who handled nanoparticles did so on Mondays, not all participants were present for all biological data collection sessions and not all participants provided blood samples.
*Ratio of the geometric mean in the handled on Monday group to the geometric mean in the not handled group.
CRP, C-reactive protein.