Table 1

Half-lives for PFOS, PFHxS and PFOA in longitudinally followed humans

ReferenceSettingModelSubjectsInitial PFAS level (ng/mL, serum)Half-life (years)
PFOSPFHxSPFOA
Olsen et al4Retired fluorochemical workers, followed 5 years
Repeated samplings with batch-wise analysis
First-order elimination
First and last sample
22 men,
2 women
Age 55–75
Median (range)
PFOS: 626 (145–3490)
PFHxS: 193 (16–1295)
PFOA: 408 (72–5100)
Median 4.6, range 2.4–21.7
GM 4.8
95% CI 4.0 to 5.8
Median 7.1, range 2.2–27.0
GM 7.3
95% CI 5.8 to 9.2
Median 3.4, range 1.5–9.1
GM 3.5
95% CI 3.0 to 4.1
Brede et al5Drinking water exposure to PFOA, follow-up 2 years after installation of charcoal filtersFirst-order elimination
First and last sample
20 children
22 mothers
23 men
Median (range)
PFOS: ≈9 (2.6–33.3)
PFHxS: ≈2.0 (<0.1–2.7)
PFOA: ≈24 (6.4–77.5)
(Relative reduction 2006–2008, 22% in women, 25% in men)(Relative reduction 2006–2008, 30% in women, 14% in men)GM 3.26 years
(range 1.03–14.67)
(relative reduction 2006–2008, 39% in women, 25% in men)
Bartell et al12Drinking water exposure to PFOA, follow-up after installation of charcoal filter
Repeated sampling, follow-up after 1 year
First-order elimination
Mixed models, five samples per person
100 men
100 women
Age 53±15
Mean, SD
PFOA 180±209
Average 2.3
95% CI 2.1 to 2.4
No sex-dependence
Gomis et al13Ski waxers, followed after marked reduction of occupational exposure4 menRange 250–1050Median 2.4, range 2.0–2.8
Worley et al11Drinking water exposure to PFAS, emanating from contaminated sewage sludge applied to agricultural fields; follow-up after 6 yearsOne-compartment pharmacokinetic model
First and last sample
First sample:
63 men, 90 women
Average 52
Last sample:
22 men, 23 women
GM
PFHxS: 6.4
PFOS: 39.8
PFOA: 16.3
Average 3.3Average 15.5Average 3.9
  • PFHxS, perfluorohexane sulfonate; PFOA, perfluorooctanoate; PFOS, perfluorooctane sulfonate.