HRs for subsequent work disability* by childhood adversity and low adult socioeconomic status (SES)
| Exposure | Model 1† | Model 2‡ | |||
| N/events | HR | 95% CI | HR | 95% CI | |
| Work disability, any cause | 31 473/11 820 | ||||
| Neither | 7342/2035 | 1.00 | 1.00 | ||
| Childhood adversity only | 10 613/3361 | 1.15 | 1.09 to 1.22 | 1.08 | 1.02 to 1.14 |
| Low adult SES only | 4868/2188 | 1.71 | 1.60 to 1.82 | 1.52 | 1.42 to 1.62 |
| Both | 8650/4236 | 1.95 | 1.85 to 2.06 | 1.62 | 1.53 to 1.71 |
| Synergy index | 1.11 | 0.96 to 1.27 | 1.03 | 0.85 to 1.25 | |
| Musculoskeletal (ICD-10 M00-M99) | 31 473/4889 | ||||
| Neither | 7342/603 | 1.00 | 1.00 | ||
| Childhood adversity only | 10 613/1036 | 1.18 | 1.06 to 1.31 | 1.11 | 1.00 to 1.23 |
| Low adult SES only | 4868/1099 | 2.78 | 2.50 to 3.08 | 2.38 | 2.14 to 2.64 |
| Both | 8650/2151 | 3.15 | 2.87 to 3.46 | 2.53 | 2.29 to 2.79 |
| Synergy index | 1.10 | 1.01 to 1.20 | 1.03 | 0.93 to 1.15 | |
| Mental (ICD-10 F00-F99) | 31 473/2357 | ||||
| Neither | 7342/364 | 1.00 | 1.00 | ||
| Childhood adversity only | 10 613/813 | 1.57 | 1.38 to 1.78 | 1.40 | 1.23 to 1.59 |
| Low adult SES only | 4868/327 | 1.34 | 1.15 to 1.57 | 1.21 | 1.03 to 1.42 |
| Both | 8650/853 | 1.96 | 1.72 to 2.22 | 1.55 | 1.36 to 1.78 |
| Synergy index | 1.05 | 0.91 to 1.22 | 0.91 | 0.74 to 1.12 | |
| Other (ICD-10 not F or M) | 31 473/7019 | ||||
| Neither | 7342/1320 | 1.00 | 1.00 | ||
| Childhood adversity only | 10 613/2073 | 1.07 | 1.00 to 1.15 | 1.02 | 0.95 to 1.10 |
| Low adult SES only | 4868/1257 | 1.40 | 1.29 to 1.52 | 1.26 | 1.16 to 1.36 |
| Both | 8650/2369 | 1.52 | 1.42 to 1.63 | 1.29 | 1.20 to 1.39 |
| Synergy index | 1.09 | 0.88 to 1.36 | 1.04 | 0.73 to 1.48 | |
*Sickness absence >9 days or work disability pension,
†Model 1 adjusted for sex, age,
‡Model 2 adjusted for sex, age, marital status, smoking, heavy alcohol use, physical activity, body mass index, chronic disease, psychological distress, job strain, shift work and type of job contract.
ICD-10, International Classification of Diseases 10th revision diagnosis codes.