ASL, n=63 | HCC, n=32 | Unspecified liver cancer, n=36 | |||||||
n | HR | 95% CI | n | HR | 95% CI | n | HR | 95% CI | |
Cumulative exposure (low cut-points)* | |||||||||
<63 ppm-years | 3 | Ref | 4 | Ref | |||||
63 to <287 ppm-years | 3 | 1.0 | 0.2 to 5.1 | 3 | 0.8 | 0.2 to 3.5 | |||
287 to <865 ppm-years | 4† | Ref | 1 | 0.3 | 0.03 to 3.0 | 5 | 1.2 | 0.3 to 4.4 | |
865 to <2271 ppm-years | 9 | 6.5 | 2.0 to 21.0 | 4 | 1.1 | 0.3 to 5.1 | 6 | 1.3 | 0.4 to 4.6 |
≥2271 ppm-years | 50 | 36.3 | 13.1 to 100.5 | 21 | 5.3 | 1.6 to 17.7 | 18 | 3.6 | 1.2 to 10.6 |
Cumulative exposure (high cut-points)‡ | |||||||||
<1021 ppm-years | 6 | Ref | 8 | Ref | 13 | Ref | |||
1021 to <3301 ppm-years | 12 | 5.4 | 2.0 to 14.3 | 4 | 1.2 | 0.4 to 3.8 | 7 | 1.3 | 0.5 to 3.2 |
3301 to <5686 ppm-years | 11 | 18.3 | 6.8 to 49.4 | 7 | 7.2 | 2.6 to 20.0 | 9 | 6.0 | 2.5 to 13.9 |
5686 to <10 551 ppm-years | 18 | 38.1 | 15.1 to 96.0 | 6 | 7.3 | 2.5 to 21.1 | 4 | 3.2 | 1.0 to 9.7 |
≥10 551 ppm-years | 16 | 73.6 | 28.8 to 188.4 | 7 | 18.8 | 6.8 to 51.9 | 3 | 5.2 | 1.5 to 18.2 |
*Low cut-points are based on quintiles of cumulative exposure for the entire cohort.
†Due to zero cases in the referent group, one case in the second quintile and three in the third quintile, the first three quintiles have been collapsed to form a single referent category.
‡High cut-points are based on quintiles of cumulative exposure for all liver cancers in the entire cohort.
ASL, angiosarcoma of the liver; HCC, hepatocellular carcinoma; Ref, referent.