Table 4

RRs and 95% CIs* for ever use of OP insecticides, compared to never use, for various cancers diagnosed five or more years after study enrolment among AHS spouses

		OPs			Malathion			Diazinon			Chlorpyrifos			Terbufos
	N_total†	N‡	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI
All sites§	1953	528	1.08	0.94 to 1.23	411	1.04	0.91 to 1.18	209	1.08	0.93 to 1.25	82	1.05	0.79 to 1.38	64	1.17	0.83 to 1.66
Breast§	740	206	1.21	0.98 to 1.49	156	1.10	0.89 to 1.35	88	1.24	0.99 to 1.56	36	1.45	0.97 to 2.18	27	1.61	0.96 to 2.72
ER+PR+	431	122	1.22	0.93 to 1.61	95	1.11	0.85 to 1.45	46	1.10	0.81 to 1.51	19	1.20	0.68 to 2.11	15	1.39	0.68 to 2.81
ER−PR−	115	35	1.19	0.71 to 1.99	25	1.04	0.62 to 1.74	16	1.48	0.86 to 2.55
Colon	143	35	0.87	0.52 to 1.44	29	0.95	0.58 to 1.57	15	1.06	0.60 to 1.87
Leukaemia	48	15	0.92	0.41 to 2.11	11	0.79	0.34 to 1.85
Lung	124	29	0.81	0.46 to 1.42	26	1.11	0.63 to 1.93	13	1.06	0.56 to 2.00
Melanoma	72	21	1.02	0.53 to 1.97	15	0.82	0.42 to 1.59
NHL	152	46	1.10	0.69 to 1.74	27	0.60	0.37 to 0.98	17	1.14	0.66 to 1.96
FL	30	11	1.02	0.38 to 2.76
MM	27	11	3.00	1.08 to 8.34
Ovary§	61	18	1.55	0.75 to 3.18	15	1.28	0.64 to 2.56	10	1.88	0.93 to 3.78
Pancreas	35	14	1.62	0.65 to 4.08	12	1.46	0.62 to 3.44
Rectum	44	11	0.96	0.39 to 2.41
Thyroid	73	21	1.41	0.74 to 2.69	19	2.22	1.18 to 4.17
Uterus§	170	47	1.03	0.66 to 1.59	37	1.09	0.71 to 1.67	15	0.81	0.47 to 1.41

		Dichlorvos			Phorate			Fonofos			Coumaphos			Parathion
	N_total	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI
All sites§	1953	53	0.95	0.72 to 1.26	42	0.86	0.60 to 1.22	42	0.90	0.61 to 1.33	27	1.00	0.68 to 1.47	26	1.20	0.81 to 1.79
Breast§	740	19	1.05	0.66 to 1.67	16	0.94	0.53 to 1.65	12	0.66	0.33 to 1.31	15	1.64	0.98 to 2.74	13	1.72	0.99 to 2.99
ER+PR+	431	14	1.21	0.70 to 2.08	10	0.99	0.48 to 2.03

*Adjusted for age, race, state, pack-years smoked, family history of cancer, alcohol consumption, BMI, education, home and garden pesticide application and correlated/associated pesticide use.
†Total cases.
^‡Exposed cases.
^§Additionally adjusted for menopause status at enrolment, number of live births, and oral contraceptive use.
AHS, Agricultural Health Study; BMI, body mass index; ER, estrogen receptor; FL, follicular Lymphoma; MM, multiple Myeloma; NHL, non-Hodgkin Lymphoma; OP, organophosphates; PR, progesterone receptor; RR, relative risks.