Table 2

RRs and 95% CIs* for ever use of OP insecticides, compared to never use, for various cancers among AHS spouses

		Any OP			Malathion			Diazinon			Chlorpyrifos			Terbufos
	N_total†	N‡	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI
All sites§	2712	718	1.08	0.97 to 1.21	558	1.03	0.92 to 1.15	277	1.04	0.91 to 1.18	108	1.03	0.81 to 1.3	88	1.26	0.94 to 1.69
Brain	38	14	1.29	0.53 to 3.12	11	1.57	0.65 to 3.78
Breast§	1059	296	1.20	1.01 to 1.43	223	1.05	0.88 to 1.26	118	1.14	0.93 to 1.38	50	1.41	1.00 to 1.99	37	1.52	0.97 to 2.36
ER+PR+	595	165	1.14	0.90 to 1.44	124	1.00	0.79 to 1.26	62	1.07	0.82 to 1.40	28	1.37	0.86 to 2.19	21	1.41	0.78 to 2.55
ER−PR−	171	52	1.26	0.83 to 1.92	40	1.17	0.77 to 1.78	20	1.21	0.75 to 1.96	11	2.26	1.07 to 4.75
Colon	204	47	0.87	0.56 to 1.33	38	0.89	0.58 to 1.37	19	0.98	0.59 to 1.61
Leukaemia	63	19	0.83	0.40 to 1.71	14	0.73	0.34 to 1.54
Lung	165	35	0.77	0.46 to 1.28	30	1.00	0.60 to 1.65	15	0.92	0.52 to 1.64
Melanoma	117	30	0.98	0.57 to 1.67	23	0.90	0.52 to 1.53
NHL	194	53	1.01	0.66 to 1.53	34	0.64	0.41 to 0.99	18	0.93	0.56 to 1.56				10	1.54	0.59 to 4.03
FL	38	13	1.24	0.51 to 3.01
MM	37	12	1.78	0.70 to 4.52
CLL/SLL/PLL/MCL	35	10	1.15	0.43 to 3.09
Ovary§	85	23	1.46	0.78 to 2.71	16	0.89	0.48 to 1.67	13	1.87	1.02 to 3.43
Pancreas	47	16	1.46	0.64 to 3.32	14	1.50	0.69 to 3.26
Rectum	61	15	1.23	0.56 to 2.68	12	0.92	0.43 to 1.97
Thyroid	91	24	1.27	0.70 to 2.30	22	2.04	1.14 to 3.63
Uterus§	231	72	1.19	0.83 to 1.72	58	1.28	0.90 to 1.83	25	1.06	0.69 to 1.64	10	0.85	0.38 to 1.89

		Dichlorvos			Phorate			Fonofos			Coumaphos			Parathion
	N_total	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI	N	RR	95% CI

All sites§	2712	81	1.08	0.86 to 1.35	55	0.81	0.59 to 1.10	54	0.86	0.61 to 1.20	39	1.08	0.78 to 1.49	34	1.18	0.83 to 1.66
Breast§	1059	33	1.19	0.84 to 1.70	22	0.88	0.54 to 1.42	17	0.65	0.36 to 1.15	18	1.30	0.81 to 2.08	14	1.26	0.74 to 2.15
ER+PR+	595	23	1.34	0.88 to 2.05	15	0.96	0.52 to 1.77	10	0.59	0.28 to 1.26	10	1.23	0.65 to 2.30

*Adjusted for age, race, state, pack-years smoked, family history of cancer, alcohol consumption, BMI, education, lawn/garden pesticide application and correlated/associated pesticide use.
†Total cases.
‡Exposed cases.
§Additionally adjusted for menopause status at enrolment, number of live births and oral contraceptive use.
AHS, Agricultural Health Study; BMI, body mass index; CLL, chronic lymphocytic leukaemia; ER, estrogen receptor; FL, follicular lymphoma; MCL, mantle cell lymphoma; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; OP, organophosphates; PLL, prolymphocytic leukaemia; PR, progesterone receptor; SLL, small lymphocytic lymphoma RR, relative risks.