Any OP | Malathion | Diazinon | Chlorpyrifos | Terbufos | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ntotal† | N‡ | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | |
All sites§ | 2712 | 718 | 1.08 | 0.97 to 1.21 | 558 | 1.03 | 0.92 to 1.15 | 277 | 1.04 | 0.91 to 1.18 | 108 | 1.03 | 0.81 to 1.3 | 88 | 1.26 | 0.94 to 1.69 |
Brain | 38 | 14 | 1.29 | 0.53 to 3.12 | 11 | 1.57 | 0.65 to 3.78 | |||||||||
Breast§ | 1059 | 296 | 1.20 | 1.01 to 1.43 | 223 | 1.05 | 0.88 to 1.26 | 118 | 1.14 | 0.93 to 1.38 | 50 | 1.41 | 1.00 to 1.99 | 37 | 1.52 | 0.97 to 2.36 |
ER+PR+ | 595 | 165 | 1.14 | 0.90 to 1.44 | 124 | 1.00 | 0.79 to 1.26 | 62 | 1.07 | 0.82 to 1.40 | 28 | 1.37 | 0.86 to 2.19 | 21 | 1.41 | 0.78 to 2.55 |
ER−PR− | 171 | 52 | 1.26 | 0.83 to 1.92 | 40 | 1.17 | 0.77 to 1.78 | 20 | 1.21 | 0.75 to 1.96 | 11 | 2.26 | 1.07 to 4.75 | |||
Colon | 204 | 47 | 0.87 | 0.56 to 1.33 | 38 | 0.89 | 0.58 to 1.37 | 19 | 0.98 | 0.59 to 1.61 | ||||||
Leukaemia | 63 | 19 | 0.83 | 0.40 to 1.71 | 14 | 0.73 | 0.34 to 1.54 | |||||||||
Lung | 165 | 35 | 0.77 | 0.46 to 1.28 | 30 | 1.00 | 0.60 to 1.65 | 15 | 0.92 | 0.52 to 1.64 | ||||||
Melanoma | 117 | 30 | 0.98 | 0.57 to 1.67 | 23 | 0.90 | 0.52 to 1.53 | |||||||||
NHL | 194 | 53 | 1.01 | 0.66 to 1.53 | 34 | 0.64 | 0.41 to 0.99 | 18 | 0.93 | 0.56 to 1.56 | 10 | 1.54 | 0.59 to 4.03 | |||
FL | 38 | 13 | 1.24 | 0.51 to 3.01 | ||||||||||||
MM | 37 | 12 | 1.78 | 0.70 to 4.52 | ||||||||||||
CLL/SLL/PLL/MCL | 35 | 10 | 1.15 | 0.43 to 3.09 | ||||||||||||
Ovary§ | 85 | 23 | 1.46 | 0.78 to 2.71 | 16 | 0.89 | 0.48 to 1.67 | 13 | 1.87 | 1.02 to 3.43 | ||||||
Pancreas | 47 | 16 | 1.46 | 0.64 to 3.32 | 14 | 1.50 | 0.69 to 3.26 | |||||||||
Rectum | 61 | 15 | 1.23 | 0.56 to 2.68 | 12 | 0.92 | 0.43 to 1.97 | |||||||||
Thyroid | 91 | 24 | 1.27 | 0.70 to 2.30 | 22 | 2.04 | 1.14 to 3.63 | |||||||||
Uterus§ | 231 | 72 | 1.19 | 0.83 to 1.72 | 58 | 1.28 | 0.90 to 1.83 | 25 | 1.06 | 0.69 to 1.64 | 10 | 0.85 | 0.38 to 1.89 | |||
Dichlorvos | Phorate | Fonofos | Coumaphos | Parathion | ||||||||||||
Ntotal | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | N | RR | 95% CI | |
All sites§ | 2712 | 81 | 1.08 | 0.86 to 1.35 | 55 | 0.81 | 0.59 to 1.10 | 54 | 0.86 | 0.61 to 1.20 | 39 | 1.08 | 0.78 to 1.49 | 34 | 1.18 | 0.83 to 1.66 |
Breast§ | 1059 | 33 | 1.19 | 0.84 to 1.70 | 22 | 0.88 | 0.54 to 1.42 | 17 | 0.65 | 0.36 to 1.15 | 18 | 1.30 | 0.81 to 2.08 | 14 | 1.26 | 0.74 to 2.15 |
ER+PR+ | 595 | 23 | 1.34 | 0.88 to 2.05 | 15 | 0.96 | 0.52 to 1.77 | 10 | 0.59 | 0.28 to 1.26 | 10 | 1.23 | 0.65 to 2.30 |
*Adjusted for age, race, state, pack-years smoked, family history of cancer, alcohol consumption, BMI, education, lawn/garden pesticide application and correlated/associated pesticide use.
†Total cases.
‡Exposed cases.
§Additionally adjusted for menopause status at enrolment, number of live births and oral contraceptive use.
AHS, Agricultural Health Study; BMI, body mass index; CLL, chronic lymphocytic leukaemia; ER, estrogen receptor; FL, follicular lymphoma; MCL, mantle cell lymphoma; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; OP, organophosphates; PLL, prolymphocytic leukaemia; PR, progesterone receptor; SLL, small lymphocytic lymphoma RR, relative risks.