Association between genetic polymorphisms and fibrotic pleuropulmonary changes
| Phenotype | Gene | Polymorphism* | β Coefficient† | p Value |
|---|---|---|---|---|
| Interstitial lung fibrosis | NLRP3 | rs35829419 | 0.078 | 0.013 |
| Visceral pleural fibrosis | TGFB1 | rs2241718 | −0.660 | 0.044 |
| Pleural plaques | ||||
| Greatest thickness | CARD8 | rs2043211 | 0.076 | 0.015 |
| Calcification | TIMP2 | rs2277698 | 0.063 | 0.037 |
Covariates used in the analysis: sex, age, pack-years and years of asbestos exposure.
*Three levels of genotypes (the wild type homozygotes, heterozygotes, variant homozygotes) were included in the model.
†Standardised β coefficient.