Distribution of TGFB1 haplotypes according to the degree of pleural plaque calcification
| Haplotype | No calcification,* n (%)† | Calcification, n (%)† | OR (95% CI)‡ | Mild§ calcification, n (%)† | OR (95% CI)‡ | High§ calcification, n (%)† | OR (95% CI)‡ |
|---|---|---|---|---|---|---|---|
| rs1800469–rs1800470 | |||||||
| GT | 176 (67.7) | 925 (57.2) | 1.0 | 359 (58.7) | 1.0 | 566 (56.3) | 1.0 |
| GC | 59 (22.7) | 454 (28.1) | 1.52 (1.09 to 2.11) | 165 (27.0) | 1.42 (0.99 to 2.03) | 289 (28.7) | 1.49 (1.04 to 2.14) |
| AT | 20 (7.7) | 214 (13.2) | 1.95 (1.18 to 3.22) | 77 (12.6) | 1.86 (1.09 to 3.16) | 137 (13.6) | 1.96 (1.15 to 3.36) |
| AC | 5 (1.9) | 25 (1.5) | 0.96 (0.35 to 2.64) | 11 (1.8) | 1.13 (0.38 to 3.4) | 14 (1.4) | 0.66 (0.21 to 2.01) |
*Reference category.
†Data are presented as number of chromosomes (%).
‡Adjusted for age, sex, pack-years and years of asbestos exposure.
§Calcification was considered as mild if it was sparse and high if a considerable part/nearly all of the pleural plaques were calcified.