Distribution of NLRP3 and TIMP2 genotypes according to the existence and severity of radiological changes
| Interstitial lung fibrosis | |||||||
|---|---|---|---|---|---|---|---|
| Genotype | No changes* | Any changes | OR (95% CI)† | Subnormal‡ changes | OR (95% CI)† | Pathological‡ changes | OR (95% CI)† |
| NLRP3 rs35829419 | |||||||
| Gln705Gln | 182 (92.4) | 661 (88.8) | 1.0 | 589 (89.9) | 1.0 | 72 (87.8) | 1.0 |
| Gln705Lys or Lys705Lys | 15 (7.6) | 83 (11.2) | 1.57 (0.87 to 2.82) | 73 (11.0) | 1.47 (0.82 to 2.67) | 10 (12.2) | 2.44 (0.97 to 6.14) |
| Calcification of pleural plaques | |||||||
| Genotype | No calcification* | Calcification | OR (95% CI)† | Mild§ calcification | OR (95% CI)† | High§ calcification | OR (95% CI)† |
| TIMP2 rs2277698 | |||||||
| G853G | 107 (83.6) | 617 (77.1) | 1.0 | 238 (79.1) | 1.0 | 379 (76.0) | 1.0 |
| G853A or A853A | 21 (16.4) | 183 (22.9) | 1.58 (0.95 to 2.65) | 63 (20.9) | 1.36 (0.78 to 2.38) | 120 (24.0) | 1.90 (1.09 to 3.33) |
Data are presented as n (%) except as noted.
*Reference category.
†Adjusted for age, sex, pack-years and years of asbestos exposure.
‡The changes were considered as mild if the radiological score was <2 and severe if the radiological score was ≥2.
§The calcification was considered as mild if it was sparse and high if a considerable part/nearly all of the pleural plaques were calcified.