Total | Men | Women | |||||||
---|---|---|---|---|---|---|---|---|---|
Cases | Person-years in subcohort | Adjusted HR* (95% CI) | Cases | Person-years in subcohort | Adjusted HR* (95% CI) | Cases | Person-years in subcohort | Adjusted HR* (95% CI) | |
Ever exposed | |||||||||
Background | 2931 | 17726 | 1 | 2106 | 8434 | 1 | 825 | 9293 | 1 |
Low/high | 3220 | 18461 | 1.02 (0.93 to 1.13) | 2390 | 9214 | 1.03 (0.91 to 1.16) | 830 | 9247 | 0.96 (0.83 to 1.12) |
Exposure duration (low or high exposed) (HR†/10 years) | 3220 | 18461 | 0.98 (0.95 to 1.02) | 4496 | 17 647 | 0.97 (0.91 to 1.02) | 1655 | 18540 | 0.87 (0.77 to 0.98) |
Cumulative exposure | |||||||||
0 unit-years | 2931 | 17726 | 1 | 2106 | 8434 | 1 | 825 | 9293 | 1 |
0.5–9 unit-years | 839 | 6626 | 1.07 (0.92 to 1.24) | 348 | 1432 | 0.97 (0.76 to 1.24) | 491 | 5193 | 1.09 (0.90 to 1.31) |
9.5–28 unit-years | 959 | 5864 | 1.04 (0.91 to 1.19) | 682 | 2484 | 1.11 (0.93 to 1.33) | 277 | 3380 | 0.86 (0.71 to 1.04) |
28.5–208 unit-years | 1422 | 5972 | 0.99 (0.87 to 1.14) | 1360 | 5298 | 1.00 (0.87 to 1.16) | 62 | 674 | 0.91 (0.63 to 1.31) |
Test for trend‡ | p=0.27 | p=0.20 | p=0.09 | ||||||
Test for trend among exposed only§ | p=0.26 | p=0.15 | p=0.07 |
*Adjusted for age at baseline, sex, smoking, attained education level, alcohol consumption and body mass index.
†HR.
‡Test for linear trend calculated by entering cumulative exposure as a continuous variable in the model.
§Test for linear trend calculated by entering cumulative exposure as a continuous variable in the model among ever low- and high-exposed subjects only.