Table 2 Prevalence of congenital malformations by subgroup in the PELAGIE cohort
Minor malformationsMajor malformations
No*No† (%‡)
3484 (2.79)
Subgroup
Nervous system04 (0.13)
Eye01 (0.03)
Ear, face and neck100 (–)
Congenital heart disease06 (0.20)
Periphery vascular60 (–)
Respiratory10 (–)
Oro-facial clefts08 (0.27)
Digestive system12 (0.06)
Abdominal wall defects01 (0.03)
Urinary313 (0.43)
Female genital20 (–)
Male genital1112 (0.40)
Limb320 (0.66)
Musculoskeletal01 (0.03)
Cutaneous03 (0.10)
Chromosomal011 (0.36)
Genetic syndromes04 (0.13)
  • *Three live births had two minor malformations.

  • †One live birth and one elective abortion had two major malformations.

  • ‡Rate of major malformations among live births, elective late abortions and fetal deaths (n = 3015).