A | At least one meta-analysis, systematic review, or RCT rated as 1++, and directly applicable to the target population; or a systematic review of RCTs or a body of evidence consisting principally of studies rated as 1+, directly applicable to the target population, and showing overall consistency of results |
B | A body of evidence including studies rated as 2++, directly applicable to the target population, and showing overall consistency of results; or extrapolated evidence from studies rated as 1++ or 1+ |
C | A body of evidence including studies rated as 2+, directly applicable to the target population and showing overall consistency of results; or extrapolated evidence from studies rated as 2++ |
D | Evidence level 3 or 4; or extrapolated evidence from studies rated as 2+ |