Comparison of predicted hazard ratios based on present analyses of lung cancer mortality in the diatomaceous earth cohort study
| Cumulative silica exposure (lag 10) | P-spline* | P-spline† | Linear‡ |
|---|---|---|---|
| All Cox models include the same covariates in additional to cumulative silica exposure. | |||
| *Cox regression with P-splines for exposure based on complete data (fig 3). | |||
| †Cox regression with P-splines for exposure trimmed to exclude two controls (fig 3). | |||
| ‡Cox regression with linear term for natural log of exposure based on complete data. | |||
| 0 | 1.0 | 1.0 | 1.0 |
| 1 | 1.3 | 1.3 | 1.5 |
| 5 | 3.1 | 3.1 | 1.8 |
| 10 | 5.3 | 5.3 | 2.0 |
| 30 | 3.8 | 7.1 | 2.2 |
| 40 | 2.5 | – | 2.3 |