Effects of exposure to carbon disulphide on the risk factors of cardiovascular disease in the follow up survey
| Non-exposed workers | Ex-CS2 workers | CS2 exposed workers | p value (ANOVA) | |
|---|---|---|---|---|
| †Arithmetic mean (SD); ‡geometric mean (GSD). | ||||
| §Subjects with non-fasting samples were excluded though inclusion of those showed similar results (n = 233 for CS2 group, 124 for ex-CS2 group, and 321 for non-exposed group, respectively). | ||||
| **p<0.05 by ANOVA followed by Dunnett’s t test; *p<0.05 compared to the non-exposed group. | ||||
| Lipid metabolism | (n = 347) | (n = 127) | (n = 253) | |
| Total cholesterol (mg/dl)‡ | 195 (1.2) | 193 (1.2) | 198 (1.2) | 0.32 |
| HDL cholesterol (mg/dl)‡ | 54 (1.3) | 54 (1.3) | 58 (1.3)* | <0.01** |
| LDL cholesterol (mg/dl)‡ | 119 (1.3) | 117 (1.3) | 118 (1.3) | 0.93 |
| Apo-AI (mg/dl)‡ | 138 (1.2) | 139 (1.2) | 145 (1.2)* | <0.01** |
| Apo-B (mg/dl)‡ | 97 (1.3) | 96 (1.3) | 97 (1.3) | 0.87 |
| Lp(a) (mg/dl)‡ | 13 (2.6) | 11 (2.4) | 11 (2.5) | 0.31 |
| Triglycerides (mg/dl)‡,§ | 108 (1.7) | 104 (1.8) | 102 (1.8) | 0.50 |
| Coagulation-fibrinolysis system | (n = 347) | (n = 127) | (n = 253) | |
| Fibrinogen (mg/dl)‡ | 241 (1.2) | 244 (1.2) | 240 (1.3) | 0.69 |
| Tissue plasminogen activator (ng/dl)‡ | 8 (1.7) | 7 (1.7) | 8 (1.6) | 0.74 |
| D-dimer (ng/dl)‡ | 50 (1.4) | 52 (1.6) | 50 (1.5) | 0.65 |
| Plasminogen activator inhibitor-1 (ng/dl)‡ | 39 (2.3) | 40 (2.5) | 42 (2.2) | 0.52 |
| Thrombin-antithrombin complex III (ng/dl)‡ | 2.2 (3.5) | 1.8 (3.2) | 2.4 (3.1) | 0.16 |
| Blood pressure (mm Hg) | (n = 336) | (n = 130) | (n = 250) | |
| Systolic blood pressure‡ | 119 (1.1) | 118 (1.1) | 121 (1.1) | 0.05** |
| Diastolic blood pressure‡ | 71 (1.2) | 71 (1.1) | 73 (1.2) | 0.23 |
| Arterial stiffness | (n = 332) | (n = 129) | (n = 237) | |
| Aorta (pulse wave velocity, m/s)† | 6.8 (0.9) | 7.0 (0.9) | 6.6 (0.9) | 0.17 |
| (n = 325) | (n = 123) | (n = 240) | ||
| Carotid artery (maximal blood flow, cm/s)‡ | 64.7 (1.3) | 61.4 (1.2) | 64.2 (1.2) | 0.08 |