Relation between urinary cotinine, NAT2 phenotype, skin aberrations, and the a priori defined exposure groups and Sunday and weekday urinary mutagenicity levels (rev/g creatinine) of rubber manufacturing workers (n=105)
| Sunday urinary mutagenicity | Weekday urinary mutagenicity | |||
|---|---|---|---|---|
| β (SE)* | p value | β (SE)* | p value | |
| *β coefficient and standard error of estimate. | ||||
| †Relative to fast acetylation phenotype. | ||||
| ‡Minor dermatitis and/or traumata of the skin. | ||||
| §Relative to subjects with no skin aberrations at time of the study. | ||||
| ¶Relative to low TSPM mutagenicity and low surface mutagenicity (LL) exposure group. | ||||
| Intercept | 8.25 (0.35) | <0.0001 | 8.59 (0.26) | <0.0001 |
| Urinary cotinine (μg/g creatinine) | 0.27 (0.05) | <0.0001 | 0.26 (0.04) | <0.0001 |
| Slow acetylation (NAT2)† | 0.06 (0.28) | 0.83 | 0.44 (0.21) | 0.04 |
| Mild skin aberrationsठ| 0.50 (0.30) | 0.09 | 0.42 (0.22) | 0.06 |
| Major dermatitis§ | 0.04 (0.61) | 0.95 | 0.05 (0.45) | 0.91 |
| High TSPM mutagenicity and low surface mutagenicity (HL)¶ | 0.05 (0.43) | 0.91 | −0.20 (0.31) | 0.52 |
| High TSPM mutagenicity and high surface mutagenicity (HH)¶ | 0.41 (0.33) | 0.22 | 0.64 (0.25) | 0.01 |
| Technical service (TD)¶ | −0.51 (0.44) | 0.26 | 0.29 (0.33) | 0.39 |