Conditional logistic regression results for various diseases of interest
| Mortality odds ratio (95% confidence interval) by silica exposure category | |||||
|---|---|---|---|---|---|
| Disease | Ever* low/no | Medium v low/no | High v low/no | Super high v low/no | Trend direction, p value |
| COPD, chronic obstructive pulmonary disease; NS, non-significant. | |||||
| *Ever = medium, high, and super high categories combined. | |||||
| +, increasing disease risk with increasing crystalline silica exposure category; −, decreasing disease risk with increasing crystalline silica exposure category. | |||||
| Silicosis | 4.98 (4.35 to 5.71) | 2.91 (2.43 to 3.48) | 6.84 (5.73 to 8.16) | 30.5 (18.4 to 50.5) | +, p<0.001 |
| Lung cancer | 0.99 (0.98 to 1.00) | 0.88 (0.87 to 0.90) | 1.13 (1.11 to 1.15) | 1.13 (1.06 to 1.21) | +, p<0.001 |
| Stomach cancer | 0.98 (0.95 to 1.02) | 0.95 (0.91 to 1.00) | 1.04 (0.99 to 1.09) | 0.81 (0.64 to 1.03) | −, NS |
| Oesophageal cancer | 0.94 (0.91 to 0.98) | 0.85 (0.81 to 0.89) | 1.07 (1.01 to 1.13) | 1.14 (0.90 to 1.43) | −, NS |
| COPD | 1.12 (1.10 to 1.14) | 1.02 (0.99 to 1.04) | 1.29 (1.25 to 1.33) | 1.47 (1.30 to 1.66) | +, p<0.001 |
| Pulmonary tuberculosis | 1.47 (1.37 to 1.57) | 1.34 (1.23 to 1.47) | 1.60 (1.45 to 1.76) | 2.48 (1.68 to 3.65) | +, p<0.001 |
| Sarcoidosis | 0.66 (0.54 to 0.80) | 0.73 (0.57 to 0.94) | 0.58 (0.44 to 0.76) | 1.02 (0.29 to 3.56) | −, NS |
| Systemic sclerosis | 1.00 (0.84 to 1.19) | 0.91 (0.72 to 1.14) | 1.08 (0.84 to 1.40) | 2.14 (0.82 to 5.57) | +, NS |
| Systemic lupus erythematosus | 0.94 (0.80 to 1.10) | 0.88 (0.72 to 1.08) | 1.01 (0.79 to 1.29) | 1.37 (0.51 to 3.69) | −, NS |
| Rheumatoid arthritis | 1.19 (1.12 to 1.25) | 1.23 (1.15 to 1.31) | 1.11 (1.01 to 1.22) | 1.05 (0.70 to 1.57) | +, p<0.001 |
| All renal failure | 0.98 (0.97 to 0.99) | 0.99 (0.98 to 1.01) | 0.96 (0.94 to 0.98) | 1.01 (0.92 to 1.10) | −, p<0.001 |
| Acute renal failure | 0.97 (0.94 to 1.00) | 0.96 (0.93 to 1.00) | 0.99 (0.95 to 1.04) | 1.01 (0.82 to 1.24) | −, NS |
| Chronic renal failure | 0.96 (0.94 to 0.99) | 0.98 (0.95 to 1.01) | 0.93 (0.89 to 0.98) | 1.00 (0.83 to 1.21) | −, p=0.003 |
| Chronic glomerulonephritis | 0.90 (0.85 to 0.96) | 0.93 (0.87 to 1.00) | 0.85 (0.77 to 0.94) | 0.70 (0.45 to 1.10) | −, p<0.001 |
| Membranous glomerulonephritis | 0.89 (0.53 to 1.48) | 0.93 (0.47 to 1.85) | 0.89 (0.45 to 1.77) | – | −, NS |