Odds ratios and 95% CI from previous studies of fetal development and trihalomethane (THM) exposure
| Odds ratio (95% CI) | THM (μg/l) exposure group | ||||
|---|---|---|---|---|---|
| Study | Low birth weight | SGA | Preterm delivery | Highest level | Reference |
| Abbreviations: CHCl3, chloroform; ND, non-detectable; BDCM, bromodichloromethane. | |||||
| *SGA defined as lowest 10% of birth weight for each gestational week. | |||||
| †SGA defined as lowest 5% of birth weight for each gestational week. | |||||
| ‡50% CI. | |||||
| §Estimate for elevated third trimester exposure among all births. | |||||
| ¶Estimate for elevated third trimester exposure among term births. | |||||
| Dodds et al30 | 1.04 (0.92 to 1.18) | 1.08 (0.99 to 1.18)* | 0.97 (0.87 to 1.09) | >100 | <50 |
| Bove et al25–27 | 1.3 (1.1 to 1.5) | 1.0 (0.9 to 1.1) | >80 | ≤20 | |
| 1.22 (1.07 to 1.40)† | 80–100 | ≤20 | |||
| 1.42 (1.22 to 1.65)‡ | 1.50 (1.14 to 1.94)† | >100 | ≤20 | ||
| Gallagher et al29 | 2.1 (1.0 to 4.8)§ | 1.0 (0.3 to 2.8) | >60 | ≤20 | |
| 5.9 (2.0 to 17.0)¶ | >60 | ≤20 | |||
| Savitz et al24 | 1.5 (1.0 to 2.3) | 1.2 (0.8 to 1.8) | 63.4–82.7 | 40.8–63.3 | |
| 1.3 (0.8 to 2.1) | 0.9 (0.6 to 1.5) | >82.8 | 40.8–63.3 | ||
| Kramer et al28 | 1.3 (0.8 to 2.2) | 1.8 (1.1 to 2.9)† | 1.1 (0.7 to 1.6) | >10 CHCl3 | ND |
| 1.0 (0.7 to 1.5) | 1.7 (0.9 to 2.9)† | 1.0 (0.6 to 1.5) | >10 BDCM | ND | |