Independent predictors of sensitisation to laboratory animal allergens in three diagnostic models
| Questionnaire model (model 1) n=470 | Questionnaire model +IgE serology (model 2) n=468 | Questionnaire model +SPT (model 3) n=470 | |||||
|---|---|---|---|---|---|---|---|
| β (SE) | OR (95% CI) | β (SE) | OR (95% CI) | β (SE) | OR (95% CI) | ||
| *No data available for specific serum IgE to common allergens. | |||||||
| Intercept | −1.82 (0.19) | – | −2.27 (0.23) | – | −2.65 (0.26) | – | |
| History of asthmatic attacks | 0.98 (0.33) | 2.7 (1.4 to 4.9) | 0.69 (0.33) | 2.0 (1.1 to 3.8) | 0.28 (0.36) | 1.3 (0.7 to 2.7) | |
| Allergic symptoms during work | 1.03 (0.32) | 2.8 (1.5 to 5.3) | 0.94 (0.34) | 2.6 (1.3 to 5.0) | 1.01 (0.37) | 2.8 (1.3 to 5.7) | |
| Allergic symptoms during past year | 0.87 (0.33) | 2.4 (1.3 to 4.6) | 0.68 (0.35) | 2.0 (1.0 to 3.9) | 0.71 (0.38) | 2.0 (1.0 to 4.2) | |
| Time exposed to rats (h/week >20) | 0.79 (0.33) | 2.2 (1.2 to 4.2) | 0.77 (0.35) | 2.2 (1.1 to 4.2) | 0.82 (0.37) | 2.3 (1.1 to 4.6) | |
| Sex, male | 0.46 (0.25) | 1.6 (1.0 to 2.6) | 0.41 (0.26) | 1.5 (0.9 to 2.5) | 0.50 (0.27) | 1.6 (1.0 to 2.8) | |
| Total IgE >100 kU/l | Not used | – | 0.67 (0.28) | 2.0 (1.1 to 3.4) | Not used | – | |
| Positive IgE common allergens | Not used | – | 0.98 (0.26) | 2.7 (1.6 to 4.4) | Not used | – | |
| Positive SPT to non-animal common allergens (tree, or house dust mite, or grass) | Not used | – | Not used | – | 1.03 (0.28) | 2.8 (1.6 to 4.8) | |
| Positive SPT to animal common allergens (cat or dog) | Not used | – | Not used | – | 1.66 (0.29) | 5.2 (2.9 to 9.3) | |
| n | AUC (SE) | 95% CI | AUC (SE) | 95% CI | AUC (SE) | 95% CI | |
| Derivation set | 470 | 0.76 (0.03) | 0.71 to 0.82 | 0.80 (0.02) | 0.75 to 0.85 | 0.86 (0.02) | 0.82 to 0.89 |
| Validation set | 78 | 0.70 (0.08) | 0.53 to 0.86 | * | * | 0.73 (0.07) | 0.60 to 0.87 |