Mortality in male UK polyurethane foam workers with any period of “lower” or “higher” exposure to diisocyanates (n=1782), 1958–98
| Cause of death | ICD-9 | Obs | Exp | SMR (95% CI) |
|---|---|---|---|---|
| Cancers | ||||
| Lip | 140 | 0 | 0.0 | 0 |
| Tongue | 141 | 0 | 0.4 | 0 |
| Salivary gland | 142 | 0 | 0.1 | 0 |
| Mouth | 143–145 | 1 | 0.4 | 276 (7 to 1537) |
| Pharynx | 146–149 | 1 | 0.7 | 139 (4 to 773) |
| Oesophagus | 150 | 4 | 3.9 | 102 (28 to 262) |
| Stomach | 151 | 4 | 6.6 | 61 (17 to 155) |
| Small intestine | 152 | 1 | 0.2 | 531 (13 to 2960) |
| Large intestine | 153 | 10 | 6.0 | 166 (80 to 306) |
| Rectum | 154 | 6 | 3.9 | 155 (57 to 337) |
| Liver | 155.0, 155.1 | 0 | 0.9 | 0 |
| Gallbladder | 156 | 0 | 0.4 | 0 |
| Pancreas | 157 | 6 | 3.9 | 156 (57 to 338) |
| Peritoneum | 158 | 0 | 0.2 | 0 |
| Other digestive | 159 | 0 | 0.5 | 0 |
| Nose and sinuses | 160 | 0 | 0.2 | 0 |
| Larynx | 161 | 2 | 0.9 | 223 (27 to 806) |
| Lung and bronchus | 162 | 36 | 30.8 | 117 (82 to 162) |
| Pleura | 163 | 0 | 0.6 | 0 |
| Bone | 170 | 1 | 0.2 | 435 (11 to 2421) |
| Connective tissue | 171 | 2 | 0.4 | 471 (57 to 1703) |
| Melanoma | 172 | 0 | 1.0 | 0 |
| Skin, other | 173 | 1 | 0.2 | 410 (10 to 2286) |
| Breast | 175 | 0 | 0.1 | 0 |
| Prostate | 185 | 6 | 5.3 | 113 (42 to 247) |
| Testis | 186 | 0 | 0.4 | 0 |
| Other genital | 187 | 0 | 0.1 | 0 |
| Bladder | 188 | 4 | 3.1 | 130 (36 to 334) |
| Kidney | 189.0 | 0 | 2.1 | 0 |
| Other urinary | 189.1–189.9 | 0 | 0.1 | 0 |
| Eye | 190 | 0 | 0.1 | 0 |
| Brain | 191–192 | 2 | 3.0 | 66 (8 to 240) |
| Thyroid | 193 | 1 | 0.2 | 664 (17 to 3700) |
| Other endocrine glands | 194 | 0 | 0.1 | 0 |
| Secondary and other cancers | 195–199 | 7 | 6.0 | 117 (47 to 240) |
| Hodgkin’s disease | 201 | 0 | 0.7 | 0 |
| Non-Hodgkin’s lymphoma | 200, 202 | 3 | 2.5 | 118 (24 to 345) |
| Multiple myeloma | 203 | 3 | 1.2 | 245 (50 to 715) |
| Leukaemia | 204–208 | 3 | 2.5 | 122 (25 to 357) |
| All neoplasms | 140–239 | 107 | 91.1 | 117 (96 to 142) |
| Non-cancers | ||||
| Infectious and parasitic diseases | 1–139 | 2 | 2.0 | 99 (12 to 357) |
| Endocrine nutritional and metabolic diseases | 240–279 | 4 | 4.1 | 99 (27 to 252) |
| Diseases of blood | 280–289 | 1 | 0.7 | 136 (3 to 755) |
| Mental disorders | 290–319 | 0 | 1.9 | 0 |
| Diseases of nervous system | 320–389 | 2 | 4.9 | 41 (5 to 148) |
| Diseases of circulatory system | 390–459 | 150 | 138.8 | 108 (91 to 127) |
| Diseases of respiratory system | 460–519 | 28 | 26.4 | 106 (71 to 153) |
| Diseases of digestive system | 520–579 | 6 | 9.1 | 66 (24 to 143) |
| Diseases of genitourinary system | 580–629 | 2 | 2.5 | 82 (10 to 295) |
| Diseases of skin | 680–709 | 0 | 0.2 | 0 |
| Diseases of musculo skeletal system | 710–739 | 1 | 0.8 | 119 (3 to 665) |
| Accidents | 800–949 | 8 | 11.3 | 71 (31 to 140) |
| Suicide | 950–959 | 6 | 6.1 | 98 (36 to 214) |
| All causes | 319 | 303.7 | 105 (94 to 117) |