Incidence rate ratios (RRs) for bladder cancer according to occupational exposures in age adjusted and multivariable analysis; Netherlands cohort study (1986–92)
| Life time exposure index3-150 | Cases | Subcohort (person-years) | RR (95% CI)3-151 | RR (95% CI)3-152 | RR (95% CI)3-153 |
| Paint components: | |||||
| No exposure | 483 | 8967 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Low exposure tertile | 8 | 258 | 0.67 (0.31 to 1.44) | 0.74 (0.33 to 1.68) | 0.75 (0.33 to 1.72) |
| Medium exposure tertile | 20 | 262 | 1.37 (0.79 to 2.39) | 1.76 (0.96 to 3.24) | 1.78 (0.94 to 3.37 |
| High exposure tertile | 19 | 257 | 1.23 (0.71 to 2.14) | 1.29 (0.71 to 2.33) | 1.31 (0.72 to 2.40) |
| p Value for trend | 0.25 | 0.08 | 0.09 | ||
| PAHs: | |||||
| No exposure | 488 | 8864 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Low exposure tertile | 7 | 303 | 0.47 (0.21 to 1.04) | 0.47 (0.21 to 1.06) | 0.51 (0.22 to 1.19) |
| Medium exposure tertile | 13 | 298 | 0.85 (0.45 to 1.59) | 0.85 (0.44 to 1.62) | 0.97 (0.49 to 1.90) |
| High exposure tertile | 19 | 286 | 1.24 (0.72 to 2.13) | 1.24 (0.68 to 2.27) | 1.18 (0.62 to 2.24) |
| p Value for trend | 0.98 | 0.80 | 0.85 | ||
| Diesel exhaust: | |||||
| No exposure | 428 | 7910 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Low exposure tertile | 35 | 643 | 1.00 (0.68 to 1.51) | 0.98 (0.64 to 1.51) | 1.00 (0.65 to 1.54) |
| Medium exposure tertile | 31 | 580 | 0.99 (0.65 to 1.52) | 0.98 (0.62 to 1.55) | 0.96 (0.60 to 1.53) |
| High exposure tertile | 32 | 586 | 1.07 (0.70 to 1.62) | 1.21 (0.78 to 1.88) | 1.17 (0.74 to 1.84) |
| p Value for trend | 0.78 | 0.50 | 0.76 | ||
| Aromatic amines: | |||||
| No exposure | 522 | 9660 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Low exposure | 3 | 63 | 0.77 (0.21 to 2.85) | 0.63 (0.12 to 3.13) | 0.64 (0.13 to 3.22) |
| High exposure | 6 | 54 | 2.00 (0.68 to 5.88) | 1.32 (0.41 to 4.23) | 1.36 (0.42 to 4.35) |
| p Value for trend | 0.24 | 0.78 | 0.72 | ||
↵3-150 Product of probability (weights 0.15, 0.6, and 0.95)×duration (y) of exposure.
↵3-151 Adjusted for age.
↵3-152 Adjusted for age, cigarette smoking amount (cigarettes/day), and cigarette smoking duration (y).
↵3-153 Adjusted for age, other occupational exposures, cigarette smoking amount (cigarettes/day), and cigarette smoking duration (y).
PAHs=polycyclic aromatic hydrocarbons.