Work related symptoms and concentrations of metabolites of 4,4′-diphenylmethane diisocyanate (MDI; P-MDX) in plasma and of specific IgG against MDI (S-IgG-MDI) and total serum immunoglobulins IgG and IgM in 152 workers potentially exposed to sprayed or heated polyurethane glue (OR (95% CI))
| Work related symptoms OR (95% CI)5-150 | |||||
|---|---|---|---|---|---|
| Eyes (n=21) | Airways | All (n=47) | |||
| Nose (n=32) | Lower airways(n=17) | Total (n=40) | |||
| P-MDX (μg/l): | |||||
| ⩽LM | 1.05-151 | 1.05-151 | 1.05-151 | 1.05-151 | 1.05-151 |
| >LM–0.60 | 0.33 (0.08 to 1.3) | 1.3 (0.46 to 3.9) | 3.6 (0.66 to 20) | 1.5 (0.55 to 4.2) | 0.91 (0.35 to 2.4) |
| >0.60–18 | 0.51 (0.16 to 1.6) | 1.3 (0.45 to 3.9) | 3.4 (0.61 to 19) | 2.0 (0.71 to 5.4) | 1.3 (0.52 to 3.4) |
| p Value for trend | 0.3 | 0.6 | 0.2 | 0.2 | 0.5 |
| S-IgG-MDI (A): | |||||
| 0–0.08 | 1.05-151 | 1.0 | 1.05-151 | 1.0 | 1.0 |
| 0.09–0.12 | 3.2 (0.90 to 11) | 1.5 (0.52 to 4.5) | 8.2 (1.0 to 70) | 1.9 (0.69 to 5.1) | 2.2 (0.87 to 5.4) |
| 0.13–1.1 | 1.3 (0.34 to 5.3) | 2.9 (1.1 to 8.0) | 9.7 (1.2 to 81) | 3.6 (1.4 to 9.3) | 2.8 (1.1 to 68) |
| p Value for trend | 0.7 | 0.03 | 0.03 | 0.007 | 0.03 |
| S-IgG (g/l): | |||||
| 0–12.3 | 1.05-151 | 1.0 | 1.0 | 1.0 | 1.05-151 |
| 12.4–14.8 | 1.0 (0.32 to 3.4) | 2.1 (0.70 to 6.1) | 8.0 (0.94 to 68) | 2.6 (1.0 to 7.2) | 1.4 (0.56 to 3.7) |
| 14.9–23 | 0.68 (0.19 to 2.4) | 3.1 (1.1 to 8.7) | 11 (1.3 to 86) | 3.4 (1.3 to 9.0) | 2.4 (0.96 to 6.1) |
| p Value for trend | 0.5 | 0.03 | 0.02 | 0.02 | 0.06 |
| S-IgM (g/l): | |||||
| 0–0.9 | 1.0 | 1.05-151 | 1.05-151 | 1.05-151 | 1.0 |
| 1.0–1.5 | 1.1 (0.27 to 4.3) | 0.97 (0.34 to 2.8) | 1.3 (0.28 to 5.8) | 1.3 (0.51 to 3.5) | 1.5 (0.61 to 3.8) |
| 1.6–2.4 | 3.4 (1.0 to 12) | 1.7 (0.63 to 4.8) | 2.8 (0.69 to 12) | 2.0 (0.77 to 5.4) | 2.8 (1.2 to 7.1) |
| p Value for trend | 0.04 | 0.3 | 0.12 | 0.14 | 0.02 |