Characteristics and results | Author and year | ||
---|---|---|---|
Jacob and Anspach 196511 | Brodkin et al 199712 | ||
Source of material | Registry of all asbestos workers in Dresden | Asbestos workers | |
Period | 1952–64 | 1985–96 | |
In cohort (n) | 2636 | 4060 | |
With lung cancer (n) | 30 | 73 | |
Stratification by asbestosis | No, 80% had asbestosis onx ray film | Yes, by profusion of small irregular opacities on x ray film | |
Cancer site denominator | Upper + lower lobes | Upper + lower lobes | |
Lower lobe % | 68.8 | 32.91-150 | |
Profusion: | |||
<1/0 | 30.8 (8/26) | ||
1/0 | 34.8 (8/23) | ||
⩾1/1 | 33.3 (8/24) | ||
Control group | Dresden population | ⩾14254 ⩾20 pack-year smokers | |
Lower lobe % | 28.6 | 20.41-150 |
↵1-150 p<0.05, χ2 for difference=4.34.
Odds ratio calculated by authors: 1.92 (95% CI 1.03 to 3.55).
The interval between the chest x ray film and lung cancer: mean (range)=4 (0–10) y in the cohort of Brodkinet al.12