Linear regression of factors modifying annual change in FVC and FEV1, analysis based on generalised estimating equation approach among 296 exposed and referent employees
| Population subgroup and explanatory factors | FVC estimate (95% CI) (l/y) | FEV1 estimate (95% CI) (l/y) |
|---|---|---|
| Total group (n=296): | ||
| Slope | −0.0437-165(−0.030 to −0.056) | −0.0437-165 (−0.031 to −0.056) |
| Slope×sex | 0.0187-165 (0.008 to 0.029) | 0.0127-150 (0.001 to 0.022) |
| Slope×race | 0.005 (−0.003 to 0.012) | 0.0087-160 (0.002 to 0.014) |
| Slope×pack-years | −0.00037-160 (−0.0001 to −0.0005) | −0.00037-165 (−0.0001 to −0.0004) |
| Slope×BMI | −0.0377-165 (−0.019 to −0.054) | −0.0247-160(−0.008 to −0.040) |
| Slope×TDI dose | −0.00001 (−0.00002 to 0.00001) | 0.00000 (−0.00001 to 0.00001) |
| Never cigarette smokers (n=101): | ||
| Slope | −0.0317-160 (−0.008 to −0.055) | −0.0287-150 (−0.006 to −0.051) |
| Slope×sex | 0.0207-150 (0.003 to 0.037) | 0.011 (−0.005 to 0.028) |
| Slope×race | 0.006 (−0.005 to 0.017) | 0.004 (−0.006 to 0.014) |
| Slope×age | −0.00127-165 (−0.0005 to −0.0019) | −0.00117-165 (−0.0005 to −0.0018) |
| Slope×BMI | −0.0557-165 (−0.022 to −0.087) | −0.030 (−0.063 to 0.003) |
| Slope×TDI dose | −0.00002 (−0.00004 to 0.00000) | −0.00000 (−0.00003 to 0.00001) |
↵7-150 p<0.05;
↵7-160 p<0.01;
↵7-165 p<0.001.
Factor definitions: sex, woman=1 man=0; race, black=1 other=0; age=<40 at last examination; pack-years=number of cigarette pack-years at last examination; BMI=average annual gain in BMI (kg/m2) between first and last examination; TDI dose=cumulative TDI dose in ppb-months at last examination.