PT - JOURNAL ARTICLE AU - Damien M McElvenny AU - Martie van Tongeren AU - Michelle C Turner AU - Geza Benke AU - Jordi Figuerola AU - Sarah Fleming AU - Martine Hours AU - Laurel Kincl AU - Daniel Krewski AU - Dave McLean AU - Marie-Élise Parent AU - Lesley Richardson AU - Brigitte Schlehofer AU - Klaus Schlaefer AU - Siegal Sadetzki AU - Joachim Schüz AU - Jack Siemiatycki AU - Elisabeth Cardis TI - The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents AID - 10.1136/oemed-2016-104280 DP - 2017 Oct 03 TA - Occupational and Environmental Medicine PG - oemed-2016-104280 4099 - http://oem.bmj.com/content/early/2017/10/02/oemed-2016-104280.short 4100 - http://oem.bmj.com/content/early/2017/10/02/oemed-2016-104280.full AB - Background Little is known about occupational risk factors for meningioma.Objectives To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents.Methods The INTEROCC study was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure for the 12 agents. ORs for ever versus never exposed and for exposure-response using duration of exposure and cumulative exposure were derived using conditional logistic regression stratified by sex, age group, country/region, adjusted for education.Results These analyses included 1906 cases and 5565 controls. For 11 of the 12 agents, no excess risk was found for ever exposed. For ever exposure to oil mists, an elevated OR of 1.57 (95% CI 1.10 to 2.22, 51 exposed cases) was found. Statistically significant exposure-response relationships were observed with cumulative exposure (p=0.01) and duration of exposure (p=0.04). Among women, there were also significant trends for cumulative and duration of exposure to asbestos and excesses in the highest exposure categories for formaldehyde.Conclusions Most agents examined did not provoke excess risks of meningioma. The main finding from this study is that it is the first study to identify a statistical association between exposure to oil mists and meningioma. This may be a chance finding or could be due to confounding with iron exposure and further research is required to understand whether the relationship is causal.