@article {Laplanche711, author = {A Laplanche and F Clavel and J C Contassot and C Lanouziere}, title = {Exposure to vinyl chloride monomer: report on a cohort study.}, volume = {44}, number = {10}, pages = {711--715}, year = {1987}, doi = {10.1136/oem.44.10.711}, publisher = {BMJ Publishing Group Ltd}, abstract = {In 1980 a prospective exposed/non-exposed cohort study was initiated in France by the Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale (INSERM U 287) to evaluate the association between mortality and cancer morbidity and occupational exposure to vinyl chloride monomer (VCM). Eleven hundred VCM exposed subjects and 1100 VCM non-exposed controls matched for age (+/- 2 years), plant, and physician were included and followed up over a five year period for vital, health, and occupational status. The percentages of deaths observed among the exposed (1.8\%) and non-exposed subjects (1.6\%) did not differ. Eighteen (1.6\%) and 15 (1.4\%) cases of cancer were reported among exposed and non-exposed subjects, respectively (NS). One case of angiosarcoma of the liver occurred among the exposed group; six cases of lung cancer occurred among exposed subjects and two among non-exposed subjects (NS). The percentage of diseases of the circulatory system was higher (p less than 0.02) in the exposed group than in the non-exposed group: this difference was explained mainly by the high incidence of Raynaud{\textquoteright}s disease (p less than 0.006). The percentages of diseases of the respiratory system did not differ between the two groups.}, issn = {0007-1072}, URL = {https://oem.bmj.com/content/44/10/711}, eprint = {https://oem.bmj.com/content/44/10/711.full.pdf}, journal = {Occupational and Environmental Medicine} }