Metals in air pollution particles decrease whole-blood coagulation time

Inhal Toxicol. 2010 Jul;22(8):621-6. doi: 10.3109/08958371003599037.

Abstract

The mechanism underlying procoagulative effects of air pollution particle exposure is not known. The authors tested the postulate that (1) the water-soluble components of an air pollution particle could affect whole-blood coagulation time and (2) metals included in this fraction were responsible for this effect. Exposure to the water-soluble fraction of particulate matter (PM), at doses as low as 50 ng/ml original particle, significantly diminished the whole-blood coagulation time. Inclusion of deferoxamine prolonged coagulation time following the exposures to the water-soluble fraction, whereas equivalent doses of ferroxamine had no effect. Except for nickel, all metal sulfates shortened the whole-blood coagulation time. Iron and zinc were two metals with the greatest capacity to reduce the coagulation time, with an effect observed at 10 ng/ml. Finally, in contrast to the anticoagulants citrate and EDTA, their iron complexes were found to be procoagulative. The authors conclude that metals in the water-soluble fraction of air pollution particles decrease whole-blood coagulation time. These metals can potentially contribute to procoagulative effects observed following human exposures to air pollution particles.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Air Pollutants / chemistry
  • Air Pollutants / pharmacology*
  • Air Pollutants / toxicity
  • Blood Coagulation / drug effects*
  • Chelating Agents / pharmacology
  • Deferoxamine / pharmacology
  • Female
  • Ferric Compounds / pharmacology
  • Humans
  • Male
  • Metals / analysis
  • Metals / pharmacology*
  • Metals / toxicity
  • Osmolar Concentration
  • Particulate Matter / chemistry
  • Particulate Matter / pharmacology*
  • Particulate Matter / toxicity
  • Solubility
  • Spectrophotometry, Atomic
  • Sulfates / pharmacology
  • Whole Blood Coagulation Time
  • Young Adult
  • Zinc Compounds / pharmacology

Substances

  • Air Pollutants
  • Chelating Agents
  • Ferric Compounds
  • Metals
  • Particulate Matter
  • Sulfates
  • Zinc Compounds
  • ferrioxamine B
  • Deferoxamine