Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate

J Occup Environ Med. 2007 Aug;49(8):872-9. doi: 10.1097/JOM.0b013e318124a93f.

Abstract

Objective: To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes.

Methods: We conducted a longitudinal study on 454 workers and used mixed models to examine the relationship between serum PFOA and lipids and liver enzymes.

Results: One part per million (ppm) increase in serum PFOA was associated with a 1.06 mg/dL increase in total cholesterol, but was not associated with changes in triglycerides or other lipoproteins, after adjusting for potential confounders. Serum PFOA was also associated with total bilirubin (0.008 mg/dL decline/ppm) and serum aspartate aminotransferase (0.35 units increase/ppm) but not with the other liver enzymes.

Conclusions: These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Caprylates / adverse effects*
  • Caprylates / blood*
  • Chemical Industry*
  • Cholesterol / blood
  • Female
  • Fluorocarbons / adverse effects*
  • Fluorocarbons / blood*
  • Humans
  • Liver Function Tests*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Occupational Exposure*
  • Retrospective Studies
  • Triglycerides / blood

Substances

  • Biomarkers
  • Caprylates
  • Fluorocarbons
  • Triglycerides
  • perfluorooctanoic acid
  • Cholesterol