Enhanced coagulation and thrombosis are linked to a variety of cardiovascular and metabolic diseases, as well as to cancer. Many of these diseases are also associated with enhanced levels of reactive oxygen species (ROS). Indeed, ROS have been made responsible for promoting many of these diseases. They have been shown not only to be cytotoxic, but also to serve as signaling molecules in a variety of cells. Recently, evidence accumulated that ROS and the redox state are also important in the control of blood coagulation and thrombosis.