eLetters

228 e-Letters

  • Analyses of cadmium and kidney function in lead workers were adjusted for lead
    Virginia M. Weaver

    We thank Dr. Kawada for his interest in our manuscript entitled "Associations of low-level urine cadmium with kidney function in lead workers."[1] As discussed in the methods and shown in the footnotes to Tables 3 and 4 in the manuscript, we adjusted for blood and tibia lead. We have presented lead analyses in this cohort in multiple past publications[2-8] so, in order to focus on the unique cadmium associations and compl...

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  • Response to "Does self-reported computer work add biologically relevant information beyond that of objectively recorded computer work?"
    Fred Gerr

    We appreciate the careful reading of our editorial [1] by Drs. Mikkelsen and Andersen. We regret our omission of the one published NUDATA study available at the time our editorial was submitted [2]. That study reported significant associations between mouse usage time collected with memory resident software and both, acute neck pain and acute shoulder pain, among 2146 technical assistants. However, because i) median mouse...

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  • Does self-reported computer work add biologically relevant information beyond that of objectively recorded computer work?
    Sigurd Mikkelsen

    In a recent editorial Gerr et al.[1] discuss computer work and musculoskeletal outcomes based on self-reported exposure versus objective recordings using computer software. They state that only one small study (n=27) using objective recordings was published before a large study by Ijmker et al.[2], published in the same issue as the editorial. They failed to consider the results of two NUDATA papers based on more than 2...

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  • Re:Analysis of job strain effects
    Kaori Fujishiro

    We thank Dr. Mikkelsen and colleagues for their constructive comments on our paper. Our responses to their three major questions are listed below.

    1) Why did we present various formulations of job strain?

    The five formulations of job strain have been commonly reported in the literature. Often, authors chose one or two formulations and thus would not know if their results were consistent across differe...

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  • Exposure to keyboard/mouse use = keystrokes + mouse clicks + POSTURE - a missing variable that cannot be overstated
    Margit L. Bleecker

    Self-report of duration of computer use is usually overestimated. The search for a valid measure of exposure to keyboard/mouse use resulted in the development of a computer registration software. The use of this new software generated unexpected results when IJmker et al.1 found software- recorded computer use was not significantly associated with upper extremity/neck symptom onset while self-reported computer use was sig...

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  • Analysis of job strain effects
    Sigurd Mikkelsen

    Fujishiro et al.1 recently published data on the association of job demands and control with carotid artery intima-media thickness (IMT). The joined effect of demands and control (strain) was analyzed by five different strain definitions: 1. a quadrant term (median splits of demands and control), 2. combinations of tertiles of demands and control, 3. an additive term (demands minus control) , 4. a quotient term (the ra...

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  • A dose-response for asbestos
    John H. Lange

    The article by Clin et al. (1) provides additional information for a dose-response relationship with asbestos and cancer. Information where a response curve changes effect as observed from background is critical in establishing a safe exposure limit (threshold -exposure/concentration- dose). Some investigators have reported this threshold is around 25 fiber/ml-years (2); although for some members of an exposed group thi...

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  • Renal effects of cadmium exposure
    Heikki Savolainen

    Dear Editor,

    I have read with the greatest interest the convincing study on the dose-response of cadmium ions in kidneys (1). Cadmium compounds also harm the proteoglycan metabolism (2), and by using the urinary proteoglycan excretion as an indicator of cadmium effects the threshold would be at 5 microg/g creatinine (3). This agrees very well with the threshold found in the current investigation.

    1 Cha...

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  • Response to: Exposure to occupational noise and cardiovascular disease in the United States: the National Health and Nutrition Examination Survey 1999-2004. Gan et al. 68:183-190 doi:10.1136/oem.2010.055269
    Karlene S Lavelle

    Gan et al, 2011 [1] concluded that long-term, occupational noise exposure was associated with increased prevalence of coronary heart disease (CHD), for which the authors report a clear exposure-response relationship that was particularly strong for participants aged < 50 years, men and current smokers. We do not believe the results support these conclusions, particularly in light of notable study limitations.

    ...
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  • Observational Studies - Workforce Perspective?
    Christopher J Kalman

    The publication of an editorial(1) and opposing commentaries(2,3) underlines the profile OEM believes should be given to debate of the proposal for observational epidemiologic studies and their protocols to be registered in advance(4). I would however express my surprise that none of these 3 offerings make mention of the workforce perspective in their analyses of the issues. The editorial itself(1) and the commentary o...

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