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Dose–time response association between occupational asbestos exposure and pleural mesothelioma: authors’ response
  1. Aude Lacourt1,
  2. Emilie Leveque1,2,
  3. Marcel Goldberg3,4,
  4. Karen Leffondre2
  1. 1University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team EPICENE, UMR 1219, Bordeaux, France
  2. 2University Bordeaux, ISPED, INSERM, Bordeaux Population Health Research Center, Team Biostatistics, UMR 1219, Bordeaux, France
  3. 3UMS 11, INSERM, VILLEJUIF, France
  4. 4Paris Descartes University, Paris, France
  1. Correspondence to Dr Aude Lacourt, Equipe EPICENE cancer et environnement, Bordeaux Population Health Center - Inserm U1219, Université Bordeaux - ISPED, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France; aude.lacourt{at}inserm.fr

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We thank Bofetta et al1 for giving us the opportunity to clarify the design of our case–control study on pleural mesothelioma (PM),2 which has been yet described and discussed in more details elsewhere.3 4

We assembled the cases (n=496) from a French hospital-based case–control study conducted in 1987–1993 in five French regions (see Iwatsubo et al5) composed of 24 departments (over the 96 departments in metropolitan France) and incident cases (n=700) identified within the French National Mesothelioma Surveillance Programme (NMSP) in 1998–2006. The NMSP, which is coordinated by the French National Public Health Agency, has been established partly to estimate the national incidence of mesothelioma in France and thus included departments that were chosen and shown to be representative of France in terms of demographic, employment and economic activity characteristics as detailed in Goldberg et al.6 In 2006, the NMSP included 25 departments including 18 that were different from the 1987–1993 case–control study. Overall, the 1196 cases of our study were recruited in 42 different departments that were well …

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