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Shift work that involves circadian disruption and breast cancer: a first application of chronobiological theory and the consequent challenges
  1. Lin Fritschi1,
  2. J Valérie Groß2,
  3. Ursula Wild2,
  4. Jane S Heyworth3,
  5. Deborah C Glass4,
  6. Thomas C Erren2
  1. 1School of Public Health, Curtin University, Perth, Australia
  2. 2Institute and Policlinic for Occupational Medicine, Environmental Medicine and Preventive Research, University of Cologne, Cologne, Germany
  3. 3School of Population and Global Health, The University of Western Australia, Perth, Australia
  4. 4Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
  1. Correspondence to Dr Lin Fritschi, School of Public Health, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia; lin.fritschi{at}curtin.edu.au

Abstract

Objectives In 2007, the International Agency for Research on Cancer classified shift work involving circadian disruption (CD) as probably carcinogenic to humans. Circadian disruption could be conceptualised as the overlap of activity, such as work, with an individual's biological night. The latter can be approximated from a worker's chronotype (or morning/evening preference). Few previous studies have taken chronotype into account when assessing CD caused by shift work. Our objective was to test the hypothesis that women working during their biological night would be at increased risk of breast cancer.

Methods We used data from our case–control study of breast cancer to investigate associations between shift work involving CD and breast cancer risks. Previously, we had assumed that everyone working in jobs which involved work for two or more shifts between midnight and 05:00 hours was equally exposed to CD. In the present analyses, we reclassified as unexposed those who had a late chronotype in which their preferred bedtime was 2 hours after the end of their shift.

Results Only 30 of 1385 night jobs changed classification and the overall finding (OR 1.17, 95% CI 0.98 to 1.41) was not different to the original finding when chronotype was not considered.

Conclusions We found virtually no difference between our new and old classifications of exposure. However, we were not able to calculate the total number of chronodisrupted shifts over a lifetime in order to assess dose and nor were we able to determine how many women were exposed to CD when doing shifts which began before midnight. Our first practical application highlights challenges for future chronobiology-based research.

  • breast cancer
  • night work
  • chronodisruption
  • case-control

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Footnotes

  • Contributors LF, JSH, DCG and TCE designed and carried out the original study. LF, JVG, UW and TCE developed the measures of chronodisruption. LF analysed the data and wrote the first draft of the manuscript. All authors contributed in a meaningful way to the final manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval University of Western Australia HREC.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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