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Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers
  1. Meinir Jones1,
  2. Sue Blair2,
  3. Stephanie MacNeill1,
  4. Jennifer Welch1,
  5. Alice Hole1,
  6. Peter Baxter3,
  7. Paul Cullinan1
  1. 1Department of Occupational and Environmental Medicine, Imperial College, London, UK
  2. 2Occupational Health Service, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
  3. 3Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK
  1. Correspondence to Dr Meinir Jones, Department of Occupational and Environmental Medicine, Imperial College, 1B Manresa Rd, London SW36LR, UK; meinir.jones{at}imperial.ac.uk

Abstract

Objectives Drosophila melanogaster (the ‘fruit fly’) is commonly used in genetic research, but there is only one report of IgE-associated allergy in exposed workers. 4 newly identified cases prompted us to examine the extent of this problem in a university laboratory. Our aim in this study is to determine the prevalence and determinants of sensitisation to fruit flies in a population of exposed workers.

Methods In a cross-sectional study, we surveyed 286 employees working in a department carrying out research involving D. melanogaster. Sensitisation was assessed by specific IgE measurement in serum and examined in relation to symptoms and to estimated exposure to fruit flies.

Results The overall prevalence of specific sensitisation was 6% with a clear relationship to increasing frequency/intensity of exposure (p trend<0.001). Work-related eye/nose, chest or skin symptoms were reported by substantial proportions of participants but for most of these there was no evidence of specific sensitisation to fruit fly. The overall prevalence of any work-related symptoms and sensitisation was 2.4%, rising to 7.1% in those working in high exposure groups.

Conclusions We were able to demonstrate, for the first time, a clear exposure–response relationship between fruit fly exposure and specific sensitisation. Facilities housing fruit flies should carefully consider methods to reduce exposure levels in the workplace.

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Footnotes

  • Contributors MJ interpreted data, wrote the manuscript and involved in the conception and design of the study. SB acquired data, involved with the design of the study and critically reviewed the manuscript. SM interpreted the data. JW acquired the data. AH acquired the data and involved with the design of the study. PB involved with the design of the study and critically reviewed the manuscript. PC conceived and designed the study and critically reviewed the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Cambridge Local Ethics Committee—LREC 00/24.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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