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Leukaemia mortality and low-dose ionising radiation in the WISMUT uranium miner cohort (1946–2013)
  1. Michaela Kreuzer1,
  2. Christina Sobotzki1,
  3. Nora Fenske1,
  4. James W Marsh2,
  5. Maria Schnelzer1
  1. 1Federal Office for Radiation Protection, Department of Radiation Protection and Health, Neuherberg, Germany
  2. 2Public Health England, Chilton, UK
  1. Correspondence to Dr Michaela Kreuzer, Federal Office for Radiation Protection, Department of Radiation Protection and Health, Ingolstaedter Landstr. 1, Neuherberg 85764, Germany; mkreuzer{at}bfs.de

Abstract

Objectives To examine the risk of death from leukaemia in relation to occupational chronic low-level external and internal radiation exposure in a cohort of 58 972 former German uranium miners with mortality follow-up from 1946 to 2013.

Methods The red bone marrow (RBM) dose from low-linear energy transfer (LET) (mainly external γ-radiation) and high-LET (mainly radon gas) radiation was estimated based on a job-exposure matrix and biokinetic/dosimetric models. Linear excess relative risks (ERR) and 95% CIs were estimated via Poisson regression for chronic lymphatic leukaemia (CLL) and non-CLL.

Results The mean cumulative low-LET and high-LET RBM doses among the 86% radiation-exposed workers were 48 and 9 mGy, respectively. There was a positive non-significant dose-response for mortality from non-CLL (n=120) in relation to low-LET (ERR/Gy=2.18; 95% CI −0.41 to 6.37) and high-LET radiation (ERR/Gy=16.65; 95% −1.13 to 46.75). A statistically significant excess was found for the subgroup chronic myeloid leukaemia (n=31) in relation to low-LET radiation (ERR/Gy=7.20; 95% CI 0.48 to 24.54) and the subgroup myeloid leukaemia (n=99) (ERR/Gy=26.02; 95% CI 2.55 to 68.99) for high-LET radiation. The ERR/Gy tended to be about five to ten times higher for high-LET versus low-LET radiation; however, the CIs largely overlapped. Results indicate no association of death from CLL (n=70) with either type of radiation.

Conclusions Our findings indicate an increased risk of death for specific subtypes from non-CLL in relation to chronic low-LET and high-LET radiation, but no such relation for CLL.

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Footnotes

  • The research was presented as an abstract before in the HEC conference, 28 Aug–2 Sept, Munich, Germany (In: E Grill, M Müller, U Mansmann. Health-exploring complexity: an interdisciplinary systems approach HEC2016, Eur J Epidemiol 2016) and the EPICOH 2016 conference, 5–8 Sept, Barcelona, Spain

  • Contributors All authors contributed to the conception and design and interpretation of the paper. CS additionally contributed to the statistical analyses and JM contributed to the dosimetry; all authors drafted the article and revised it critically; all authors gave their final approval of the version to be published; MK is responsible for the overall content as guarantor.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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