Article Text

other Versions

PDF
Original article
Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers
  1. Nicole A H Janssen1,
  2. Maciej Strak1,2,3,
  3. Aileen Yang1,2,
  4. Bryan Hellack4,5,
  5. Frank J Kelly6,
  6. Thomas A J Kuhlbusch4,5,
  7. Roy M Harrison7,8,
  8. Bert Brunekreef2,9,
  9. Flemming R Cassee1,2,
  10. Maaike Steenhof2,
  11. Gerard Hoek2
  1. 1Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
  2. 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
  3. 3Department of Environmental Health, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands
  4. 4Air Quality & Sustainable Nanotechnology, Institute of Energy and Environmental Technology (IUTA), Duisburg, Germany
  5. 5CENIDE, University of Duisburg-Essen, Duisburg, Germany
  6. 6MRC-PHE Centre for Environment and Health, School of Biomedical Sciences, King's College London, London, UK
  7. 7Division of Environmental Health & Risk Management, School of Geography, Earth & Environmental Sciences, University of Birmingham, Birmingham, UK
  8. 8Department of Environmental Sciences, Center of Excellence in Environmental Studies, King Abdulaziz University, Jeddah, Saudi Arabia
  9. 9Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
  1. Correspondence to Dr Nicole AH Janssen, National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands; Nicole.Janssen{at}rivm.nl

Abstract

Introduction We evaluated associations between three a-cellular measures of the oxidative potential (OP) of particulate matter (PM) and acute health effects.

Methods We exposed 31 volunteers for 5 h to ambient air pollution at five locations: an underground train station, two traffic sites, a farm and an urban background site. Each volunteer visited at least three sites. We conducted health measurements before exposure, 2 h after exposure and the next morning. We measured air pollution on site and characterised the OP of PM2.5 and PM10 using three a-cellular assays; dithiotreitol (OPDTT), electron spin resonance (OPESR) and ascorbic acid depletion (OPAA).

Results In single-pollutant models, all measures of OP were significantly associated with increases in fractional exhaled nitric oxide and increases in interleukin-6 in nasal lavage 2 h after exposure. These OP associations remained significant after adjustment for co-pollutants when only the four outdoor sites were included, but lost significance when measurements at the underground site were included. Other health end points including lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP.

Conclusions We found significant associations between three a-cellular measures of OP of PM and markers of airway and nasal inflammation. However, consistency of these effects in two-pollutant models depended on how measurements at the underground site were considered. Lung function and vascular inflammatory and coagulation parameters in blood were not consistently associated with OP. Our study, therefore, provides limited support for a role of OP in predicting acute health effects of PM in healthy young adults.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.