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Exposure to chlorinated solvents and lung cancer: results of the ICARE study
  1. Francesca Mattei1,2,
  2. Florence Guida1,2,
  3. Mireille Matrat3,4,
  4. Sylvie Cenée1,2,
  5. Diane Cyr5,6,
  6. Marie Sanchez1,2,
  7. Loredana Radoi7,8,
  8. Gwenn Menvielle9,10,
  9. Fatima Jellouli7,11,
  10. Matthieu Carton5,6,
  11. Simona Bara12,
  12. Emilie Marrer13,
  13. Danièle Luce14,15,
  14. Isabelle Stücker1,2
  1. 1INSERM, UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer, Villejuif, France
  2. 2University of Paris Sud 11, UMRS 1018, Villejuif, France
  3. 3INSERM, U955, Créteil Cedex, France
  4. 4Centre Hospitalier Intercommunal, Créteil Cedex, France
  5. 5INSERM, Epidemiologic Cohorts Unit—UMS 011 INSERM-UVSQ, Villejuif, France
  6. 6University of Versailles St-Quentin, UMS 011, Villejuif, France
  7. 7INSERM, UMRS 1018, CESP Centre for Research in Epidemiology and Population Health, Epidemiology of Occupational and Social Determinants of Health, Villejuif, France
  8. 8Faculty of Dental Surgery, University Paris Descartes, Paris, France
  9. 9INSERM, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Villejuif, France
  10. 10Sorbonne University, UPMC University of Paris 06, UMR_S 1136, Pierre Louis Institute of Epidemiology and Public Health, Villejuif, France
  11. 11University of Versailles St-Quentin, UMRS 1018, Villejuif, France
  12. 12Registre des Cancers de la Manche, Cherbourg-Octeville, France
  13. 13Registre des Cancers du Haut-Rhin, Mulhouse, France
  14. 14INSERM, U 1085_IRSET, Campus de Fouillole—BP 145, Pointe-à-Pitre, Guadeloupe, French West Indies
  15. 15University of Rennes 1, Campus de Fouillole—BP 145, Pointe-à-Pitre, Guadeloupe, French West Indies
  1. Correspondence to Dr Isabelle Stücker, CESP Centre for Research in Epidemiology and Population Health, 16 avenue Paul Vaillant Couturier, Villejuif, Cedex 94807, France; isabelle.stucker{at}inserm.fr

Abstract

Objective To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology.

Methods ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case–control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made.

Results After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations.

Conclusions These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.

  • Lung Cancer
  • Chlorinated Solvents
  • Occupational Exposure
  • Case-Control Study

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