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Contact with animals and risk of oesophageal squamous cell carcinoma: outcome of a case–control study from Kashmir, a high-risk region
  1. Nazir Ahmad Dar1,2,
  2. Farhad Islami2,3,
  3. Gulzar Ahmad Bhat1,
  4. Idrees Ayoub Shah1,
  5. Muzamil Ashraf Makhdoomi1,
  6. Beenish Iqbal1,
  7. Rumaisa Rafiq1,
  8. Mohd Maqbool Lone4,
  9. Paolo Boffetta2,5
  1. 1Department of Biochemistry, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India
  2. 2The Tisch Cancer Institute and Institute for Transitional Epidemiology, Mount Sinai School of Medicine, New York, New York, USA
  3. 3Digestive Disease Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4Departments of Radiation Oncology, SK Institute of Medical Sciences, Soura Srinagar, India
  5. 5International Prevention Research Institute, Lyon, France
  1. Correspondence to Dr Nazir Ahmad Dar, The Tisch Cancer Institute and Institute for Transitional Epidemiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box No.1057, New York, NY 10029, USA; nazirramzan{at}gmail.com

Abstract

Background Several studies have reported association between animal contact and some cancer types, including lymphohaematopoietic, colon, pancreatic and neurological malignancies. We aimed to investigate the association between animal contact and risk of oesophageal squamous cell carcinoma (ESCC) in a case–control study in Kashmir, India, area with a relatively high incidence of ESCC.

Methods We recruited 703 histologically confirmed ESCC cases and 1664 controls individually matched to the cases for age, sex and district of residence. Information, including on animal contact, was obtained in face-to-face interviews using a structured questionnaire. Conditional logistic regression models were used to calculate ORs and 95% CIs.

Results As compared with no contact with animals, daily close contact was associated with an increased risk of ESCC (OR 5.99; 95% CI 3.86 to 9.31) in models adjusted for several potential confounding factors, including multiple indicators of socioeconomic status. This association persisted in subgroups following stratification by a composite wealth score and occupation. Irregular contact with animals was not associated with ESCC risk. The association between duration of animal contact and ESCC risk was mixed; however, contact for more than 50 years was associated with an increased risk (OR 3.10; 95% CI 1.53 to 6.26). Frequency (p for trend, 0.001) and duration (p for trend, <0.001) of animal contact showed dose–response association with ESCC risk.

Conclusions Our results suggest an association between long-term and daily close contact with animals and ESCC. This association needs to be investigated in further studies.

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