GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort
- 1Department of Medicine, University of British Columbia, Vancouver, Canada
- 2Department of Pediatrics, University of Manitoba, Winnipeg, Canada
- Correspondence to Dr Chris Carlsten, Vancouver General Hospital, 2775 Laurel Street, 7th Floor (The Lung Center), Vancouver, BC V5Z 1M9, Canada; chris.carlsten{at}vch.ca
- Accepted 5 December 2010
- Published Online First 7 January 2011
We recently reported1 on the risk of incident asthma associated with traffic-related air pollution in a high-risk birth cohort in Vancouver, British Columbia. We have now examined the effect of two common polymorphisms in the glutathione-s-transferase P1 (GSTP1) gene that is known to metabolise oxidative species and which has been shown previously to modify risk of allergic disease associated with nitrogen dioxide (NO2) exposure.2
At 7 years of age, 173 children were assessed for asthma by paediatric allergists and peripheral blood was obtained from these children and their parents. DNA was genotyped by the Illumina BeadArray system (Illumina, San Diego, California, USA) following the …
