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Lung function loss in relation to silica dust exposure in South African gold miners
  1. R I Ehrlich1,
  2. J E Myers1,
  3. J M te Water Naude2,
  4. M L Thompson1,3,
  5. G J Churchyard4
  1. 1Centre for Occupational and Environmental Health Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
  2. 2Asbestos Relief Trust, Cape Town, South Africa
  3. 3Department of Biostatistics, University of Washington, Seattle, USA
  4. 4Aurum Institute for Health Research, Johannesburg, South Africa
  1. Correspondence to Professor R Ehrlich, School of Public Health and Family Medicine, University of Cape Town, Observatory 7925, South Africa; rodney.ehrlich{at}uct.ac.za

Abstract

Objective To estimate exposure-response relationships between respirable dust, respirable quartz and lung function loss in black South African gold miners.

Methods 520 mineworkers aged >37 years were enrolled in a cross-sectional study. Gravimetric dust measurements were used to calculate cumulative respirable dust and quartz exposures. Excess lung function loss was defined as predicted minus observed forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). The association between excess loss and exposure was estimated, adjusting for smoking, tuberculosis and silicosis.

Results Mean service length was 21.8 years, mean respirable dust 0.37 mg/m3 and mean respirable quartz 0.053 mg/m3. After adjustment, 1 mg-yr/m3 increase in cumulative respirable dust exposure was associated with 18.7 ml mean excess loss in FVC [95% confidence interval (CI) 0.3, 37.1] and 16.2 ml in FEV1 (95% CI −0.3, 32.6). Mean excess loss with silicosis was 224.1 ml in FEV1 and 123.6 ml in FVC; with tuberculosis 347.4 ml in FEV1 and 264.3 ml in FVC.

Conclusion Despite a healthy worker effect, lung function loss was demonstrable whether due to silicosis, tuberculosis or an independent effect of dust. A miner working at a respirable dust intensity of 0.37 mg/m3 for 30 years would lose on average an additional 208 ml in FVC (95% CI 3, 412) in the absence of other disease, an impact greater than that of silicosis and comparable to that of tuberculosis. Improved dust control on the South African gold mines would reduce the risk of silicosis, tuberculosis and lung function impairment.

  • Lung function
  • silicosis
  • tuberculosis

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Footnotes

  • Funding The Safety in Mines Research Advisory Committee (SIMRAC) provided funding for this study (SIMHEALTH 606).

  • Competing interests GJC was employed by AngloGold Ashanti during the conduct of this study. RIE and JEM have written expert reports for use in silicosis litigation.

  • Ethics approval This study was conducted with the approval of the Research Ethics Committee of the Health Sciences Faculty of the University of Witwatersrand and the Medical Research Ethics Committee of Anglogold Health Services.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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