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Occupation and renal cell cancer in Central and Eastern Europe
  1. Julia E Heck (jeh61{at}columbia.edu)
  1. International Agency for Research on Cancer, France
    1. Barbara Charbotel (barbara.charbotel{at}rockefeller.univ-lyon1.fr)
    1. Université Lyon 1, France
      1. Lee E Moore (lemoore{at}mail.nih.gov)
      1. National Cancer Institute, United States
        1. Sara Karami
        1. National Cancer Institute, United States
          1. David G Zaridze
          1. Institute of Carcinogenesis, Russian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation
            1. Vsevolod Matveev
            1. N.N. Blokhin Cancer Research Center, Russian Federation
              1. Vladimir Janout
              1. Palacky University, Czech Republic
                1. Helena Kollárová
                1. Palacky University, Czech Republic
                  1. Lenka Foretova
                  1. Masaryk Memorial Cancer Institute, Czech Republic
                    1. Vladimir Bencko
                    1. Charles University, Czech Republic
                      1. Neonila Szeszenia-Dabrowska
                      1. Institute of Occupational Medicine, Poland
                        1. Jolanta Lissowska
                        1. Cancer Center and Maria Sklodowska-Curie Institute of Oncology, Poland
                          1. Dana Mates
                          1. Institute of Public Health, Romania
                            1. Gilles Ferro
                            1. International Agency for Research on Cancer, France
                              1. Wong-Ho Chow
                              1. National Cancer Institute, United States
                                1. Nathaniel Rothman
                                1. National Cancer Institute, United States
                                  1. Patricia Stewart
                                  1. National Cancer Institute, United States
                                    1. Paul Brennan (brennan{at}iarc.fr)
                                    1. International Agency for Research on Cancer, France
                                      1. Paolo Boffetta (boffetta{at}iarc.fr)
                                      1. International Agency for Research on Cancer, France

                                        Abstract

                                        Objective: Central and Eastern Europe has among the highest rates of renal cell cancer worldwide. Few studies have been conducted in these areas to investigate the possible role of occupational exposures in renal cell cancer etiology. The purpose of this study was to examine the association of renal cell cancer with employment in specific occupations and industries.

                                        Methods: From 1999-2003, we conducted a hospital-based case-control study in seven areas of the Czech Republic, Poland, Romania and Russia. A detailed occupational history was collected from renal cell cancer cases and controls, together with information on potential confounders. Odds ratios (OR) and 95% confidence intervals (CI) of cancer risk were calculated for having ever been employed in selected jobs and industries, with follow-up analyses examining duration of employment.

                                        Results: A total of 992 histologically confirmed incident renal cell cancer cases and 1,465 controls were included in the analysis. An increased risk of renal cell cancer was observed for workers in agricultural labor and animal husbandry (OR=1.43, 95% CI 1.05, 1.93), particularly among women employed as general farm workers (OR=2.73, 95% CI 1.05, 7.13). Risk gradients for agricultural work increased with longer employment. An overall increased risk of renal cell cancer was seen among architects and engineers (OR=1.89, 95% CI 1.35, 2.65), and mechanical engineers (OR=1.71, 95% CI 1.03, 2.84).

                                        Conclusions: Our data suggest an association between renal cell cancer and agricultural work, particularly among female workers.

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