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Third follow-up of a Dutch cohort occupationally exposed to chlorophenoxy herbicides, chlorophenols and dioxins
  1. Daisy Boers (d.boers{at}uu.nl)
  1. IRAS, Utrecht University, Netherlands
    1. Lützen Portengen (l.portengen{at}uu.nl)
    1. IRAS, Utrecht University, Netherlands
      1. H Bas Bueno-de-Mesquita (hb.bueno.de.mesquita{at}rivm.nl)
      1. RIVM, Netherlands
        1. Dick J J Heederik (d.heederik{at}uu.nl)
        1. University of Utrecht, Netherlands
          1. Roel Vermeulen (r.c.h.vermeulen{at}uu.nl)
          1. IRAS, Utrecht University, Netherlands

            Abstract

            Objective: A retrospective cohort study was conducted in two chlorophenoxy herbicide manufacturing factories, producing mainly 2,4,5-T (factory A) and MCPA, MCPP, and 2,4-D (factory B). Previously, we have shown elevated risks for mortality and cancer mortality in this cohort. The purpose of the current, third follow-up, is to provide an updated assessment of cause-specific mortality for both factories.

            Methods: The study population was defined as all persons working in one of the two factories during 1955-1985 for factory A, or during 1965-1986 for factory B. Analyses were done using Cox proportional hazard models, using attained age as the time-scale. Exposure to phenoxy herbicides and dioxins was expected to be different for factory A and B and the factories were therefore analyzed separately.

            Results: Previously reported increased risks for respiratory cancer, non-Hodgkin’s lymphoma and ischemic heart disease in factory A could not be confirmed in the present analysis. However, increased risks were observed for all cancers in both factory A (HR=1.31; 95% CI 0.86-2.01) and factory B (HR=1.54; 95% CI 1.00-2.37). Increased risks for urinary cancers (HR=4.2; 95% CI 0.99-17.89) and genital cancers (HR=2.93; 95% CI 0.61-14.15) were observed in factory A, consistent with earlier reported results in this population. More detailed analyses showed that this increased risk for urinary and genital cancers in exposed workers was not due to selection of healthy controls and could not be attributed to specific products or departments.

            Conclusion: The results of this study showed only slight increases in cancer mortality risk. The increased risk for urinary cancers is noteworthy, but could not be linked to a specific exposure and needs to be confirmed in similar cohorts.

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