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Ischemic Heart Disease Mortality Study among Workers with Occupational Exposure to Ammonium Perfluorooctanoate
  1. Carine J Sakr (carine.j.sakr{at}
  1. E.I. du Pont de Nemours and Company, Newark, United States
    1. J. Morel Symons (j-morel.symons{at}
    1. E.I. du Pont de Nemours and Company, Newark, United States
      1. Kim H Kreckmann (kim.kreckmann{at}
      1. E.I. du Pont de Nemours and Company, Newark, United States
        1. Robin C Leonard, Dr (rleonard{at}
        1. Department of Health, West Chester University of Pennsylvania, United States


          Objectives: Ammonium perfluorooctanoate (APFO) is a biopersistent surfactant used in the manufacture of several types of fluoropolymers. Based on previous findings of increased serum lipid levels associated with exposure to ammonium perfluorooctanoate (APFO), we evaluated ischemic heart disease (IHD) mortality in a cohort of occupationally exposed workers.

          Methods: Relative risks (RR) were estimated from exposure-response analyses of cumulative exposure measures using proportional hazards regression models.

          Results: Two hundred thirty nine IHD deaths have occurred in the cohort of 4,747 workers with work histories from 1948 through 2002. RR estimates indicate no statistically significant increased mortality risk for IHD associated with estimated cumulative exposure. We observed a positive trend only at an exposure lag of 10 years. This finding was not reproduced in other 5-year exposure lags and was attenuated when different cutpoints for exposure categorization were used.

          Conclusion: This exposure-response study shows no convincing evidence of increased IHD mortality risk for APFO-exposed workers at this plant. Further studies evaluating incidence of IHD are being conducted.

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