Article Text

other Versions

PDF
Bayesian Modeling Of Lung Cancer Risk And Bitumen Fume Exposure Adjusted For Unmeasured Confounding By Smoking
  1. Frank de Vocht (frank.devocht{at}manchester.ac.uk)
  1. The University of Manchester, United Kingdom
    1. Hans Kromhout (h.kromhout{at}uu.nl)
    1. Utrecht University, Netherlands
      1. Gilles Ferro (ferro{at}iarc.fr)
      1. International Agency for Research on Cancer, France
        1. Paolo Boffetta (boffetta{at}iarc.fr)
        1. International Agency for Research on Cancer, France
          1. Igor Burstyn (igor.burstyn{at}ualberta.ca)
          1. University of Alberta, Canada

            Abstract

            Objectives: Residual confounding can be present in epidemiological studies because information on confounding factors was not collected. A Bayesian framework, which has the advantage over frequentist methods that the uncertainty in the association between the confounding factor and exposure and disease can be reflected in the credible intervals of the risk parameter, is proposed to assess the magnitude and direction of this bias.

            Methods: To illustrate this method, bias from smoking as an unmeasured confounder in a cohort study of lung cancer risk in the European asphalt industry was assessed. A Poisson disease model was specified to assess lung cancer risk associated with career average, cumulative, and lagged bitumen fume exposure. Prior distributions for the exposure strata, as well as for other covariates, were specified as uninformative normal distributions. The priors on smoking habits were specified as a Dirichlet distributions based on smoking prevalence estimates available for a sub-cohort and assumptions about precision of these estimates.

            Results: Median bias in this example was estimated at 13%, and suggested an attenuating effect on the original exposure-disease associations. Nonetheless, the results still suggested an increased lung cancer risk, especially for average exposure.

            Conclusions: This Bayesian framework provides a method to assess the bias from an unmeasured confounding factor taking into account the uncertainty surrounding the estimate and from random sampling error. Specifically for this example, the bias arising from unmeasured smoking history in this asphalt workers’ cohort is unlikely to explain the increased lung cancer risk associated with average bitumen fume exposure found in the original study.

            Statistics from Altmetric.com

            Request permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.