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Dust and chemical exposures, and spontaneous abortion risk among women textile workers in Shanghai, China
  1. Eva Y. Wong (evawong{at}u.washington.edu)
  1. University of Washington, United States
    1. Roberta M. Ray
    1. Fred Hutchinson Cancer Research Center, United States
      1. Dao Li Gao
      1. Zhong Shan Hospital, Shanghai, China
        1. Karen J. Wernli
        1. Fred Hutchinson Cancer Research Center, United States
          1. Wenjin Li
          1. Fred Hutchinson Cancer Research Center, United States
            1. E Dawn Fitzgibbons
            1. Fred Hutchinson Cancer Research Center, United States
              1. Janice E. Camp
              1. University of Washington, Dept. of Environmental and Occupational Health Sciences, United States
                1. George Astrakianakis
                1. Occupational Health and Safety, British Columbia, Canada
                  1. Patrick J. Heagerty
                  1. University of Washington, Department of Biostatistics, United States
                    1. A J De Roos
                    1. /, United States
                      1. V L Holt
                      1. /, United States
                        1. David B. Thomas
                        1. Fred Hutchinson Cancer Research Center, United States
                          1. Harvey Checkoway (checko{at}u.washington.edu)
                          1. University of Washington, Department of Environmental and Occupational Health Sciences, United States

                            Abstract

                            Objective: To investigate possible associations between spontaneous abortion and occupational exposures in the Shanghai Textile Industry.

                            Methods: We conducted a retrospective cohort study of spontaneous abortions among 1,752 women in the Shanghai textile industry. Reproductive history was self-reported by women and occupational work histories were collected from factory personnel records. Occupational exposures were assigned by linking work history information to an industry-specific job-exposure matrix informed by factory-specific textile process information and industrial hygiene assessments. Estimates of cotton dust and endotoxin exposure were also assigned. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by multivariate logistic regression, with adjustment for age at pregnancy, education level, smoking status of woman and spouse, use of alcohol, and woman’s year of birth.

                            Results: An elevation in risk of a spontaneously aborted first pregnancy was associated with exposure to synthetic fibers (1.89, 95% CI: 1.20-3.00) and mixed synthetic and natural fibers (3.31, 95% CI: 1.30-8.42). No increased risks were observed for women working with solvents, nor were significant associations observed with quantitative cotton dust or endotoxin exposures. Associations were robust and similar when all pregnancies in a woman’s reproductive history were considered.

                            Conclusions. Occupational exposure to synthetic fibers may cause spontaneous abortions, and this possibility should be the subject of further investigation.

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