Article Text

other Versions

PDF
Degreasing and risk of non-Hodgkin lymphoma
  1. Mark P Purdue (purduem{at}mail.nih.gov)
  1. National Cancer Institute, United States
    1. Richard K. Severson (rseverson{at}med.wayne.edu)
    1. Wayne State University, United States
      1. Joanne S. Colt (coltj{at}mail.nih.gov)
      1. National Cancer Institute, United States
        1. Patricia Stewart (tstewart{at}mail.nih.gov)
        1. National Cancer Institute, United States
          1. Anneclaire J. De Roos (deroos{at}u.washington.edu)
          1. University of Washington, United States
            1. James R. Cerhan (cerhan.james{at}mayo.edu)
            1. Mayo Clinic College of Medicine, United States
              1. Wendy Cozen (wcozen{at}usc.edu)
              1. University of Southern California, United States
                1. Scott Davis (sdavis{at}fhcrc.org)
                1. University of Washington, United States
                  1. Patricia Hartge (hartgep{at}mail.nih.gov)
                  1. National Cancer Institute, United States
                    1. Maryjean Schenk (mschenk{at}med.wayne.edu)
                    1. Wayne State University, United States
                      1. Aaron Blair (blaira{at}mail.nih.gov)
                      1. National Cancer Institute, United States

                        Abstract

                        Objective: To investigate the relationship between selected solvent-related workplace tasks (degreasing, painting, gluing, stripping paint, staining) and risk of non-Hodgkin lymphoma (NHL).

                        Methods: We analyzed occupational data from a large population-based case-control study of NHL conducted in the United States. For participants reporting occupations with possible exposure to organic solvents, job-specific interview modules were administered to elicit in-depth information on solvent-related workplace tasks and other exposure-related factors (225 cases, 189 controls). Unconditional logistic regression models were fit to calculate odds ratios (OR) and 95% confidence intervals (CI) for average frequency, maximal frequency and cumulative number of hours having performed each task. Individuals with jobs rated as unexposed to organic solvents in the workplace (180 cases, 213 controls) were used as a reference group.

                        Results: We observed an increased risk of NHL among subjects in the highest category of maximal degreasing frequency (>520 hours/year: OR 2.1, 95% CI 0.9-4.9, trend test p=0.02). We found similar associations for the highest levels of average frequency and, among men, cumulative number of hours. Other solvent-related tasks were not associated with NHL.

                        Conclusion: Findings from this case-control analysis of solvent-related tasks suggest that frequent degreasing work may be associated with an elevated risk of NHL.

                        Statistics from Altmetric.com

                        Request permissions

                        If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.