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High risk occupations for Non-Hodgkin’s Lymphoma in New Zealand: case-control study
  1. Andrea Martine 't Mannetje (a.mannetje{at}massey.ac.nz)
  1. Centre for Public Health Research, New Zealand
    1. Evan Dryson (edryson{at}omspecialists.co.nz)
    1. Occupational Medicine Specialists, Auckland, New Zealand
      1. Chris Walls (cwalls{at}omspecialists.co.nz)
      1. Occupational Medicine Specialists, Auckland, New Zealand
        1. David J McLean (d.j.mclean{at}massey.ac.nz)
        1. Centre for Public Health Research, Massey University, New Zealand
          1. Fiona McKenzie (f.j.mckenzie{at}massey.ac.nz)
          1. Centre for Public Health Research, Massey University, New Zealand
            1. Milena Maule (milena.maule{at}cpo.it)
            1. Cancer Epidemiology Unit, CeRMS and CPO Piemonte, University of Turin, Italy
              1. Soo Cheng (s.k.cheng{at}massey.ac.nz)
              1. Centre for Public Health Research, Massey University, New Zealand
                1. Chris Cunningham (c.w.cunningham{at}massey.ac.nz)
                1. Research Centre for Maori Health and Development, Massey University, New Zealand
                  1. Hans Kromhout (j.kromhout{at}iras.uu.nl)
                  1. Institute for Risk Assessment Sciences, University of Utrecht, Netherlands
                    1. Paolo Boffetta (boffetta{at}iarc.fr)
                    1. International Agency for Research on Cancer, France
                      1. Aaron Blair (blaira{at}exchange.nih.gov)
                      1. Occupational and Environmental Epidemiology Branch, National Cancer Institute, United States
                        1. Neil Pearce (n.e.pearce{at}massey.ac.nz)
                        1. Centre for Public Health Research, Massey University, New Zealand

                          Abstract

                          Objectives. Previous studies into occupational risk factors for Non-Hodgkin’s Lymphoma (NHL) in New Zealand have indicated that farmers and meat workers are at increased risk for these neoplasms. We conducted a new nationwide case-control study to assess whether previously observed associations persist and to identify other occupations that may contribute to the risk of NHL in the New Zealand population. Methods. A total of 291 incident cases of NHL (age 25 to 70 years) notified to the New Zealand Cancer Registry during 2003 and 2004, and 471 population controls, were interviewed face-to-face. The questionnaire collected demographic information and a full occupational history. The relative risk for NHL associated with ever being employed in particular occupations and industries was calculated by unconditional logistic regression adjusting for age, sex, smoking, ethnicity and socio-economic status. Estimates were subsequently semi-Bayes adjusted to account for the large number of occupations and industries being considered. Results. An elevated NHL risk was observed for field crop and vegetable growers (Odds Ratio (OR) 2.74 95% Confidence Interval (95%CI) 1.04-7.25) and horticulture and fruit growing (OR 2.28 95%CI 1.37-3.79), particularly for women (OR 3.44 95%CI 0.62-18.9; OR 3.15 95%CI 1.50-6.61). Sheep and dairy farming was not associated with an increased risk of NHL. Meat processors had an elevated risk (OR 1.97, 95% 0.97-3.97), as did heavy truck drivers (OR 1.98 95%CI 0.92-4.24), workers employed in metal product manufacturing (OR 1.92 95%CI 1.12-3.28) and cleaners (OR 2.11 95%CI 1.21-3.65). After semi-Mayes adjustment the elevated risks for horticulture and fruit growing, metal product manufacturing and cleaners remained statistically significant, representing the most robust findings of this study. Conclusions. This study has confirmed that crop farmers and meat workers remain high risk occupations for NHL in New Zealand, and has identified several other occupations and industries of high NHL risk that merit further study.

                          • New Zealand
                          • Non-Hodgkin's Lymphoma
                          • case-control study
                          • farming
                          • occupation

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