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Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes
  1. Pierluigi Cocco (coccop{at}pacs.unica.it)
  1. University of Cagliari, Italy
    1. Paul Brennan (brennan{at}iarc.fr)
    1. International Agency for Research on Cancer, France
      1. Antonio Ibba (colo-k333{at}libero.it)
      1. University of Cagliari, Italy
        1. Silvia de Sanjosè Llongueras (s.sanjose{at}iconcologia.net)
        1. Catalan Institute of Oncology, Barcelona, Spain, Spain
          1. Marc Maynadié (mmaynadie{at}chu-dijon.fr)
          1. Registre des Hémopathies Malignes de Côte d’Or, Dijon, France, France
            1. Alexandra Nieters (a.nieters{at}dkfz-heidelberg.de)
            1. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany, Germany
              1. Nikolaus Becker (n.becker{at}dkfz-heidelberg.de)
              1. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany, Germany
                1. Maria G Ennas (gennas{at}unica.it)
                1. University of Cagliari, Italy, Italy
                  1. Maria G Tocco
                  1. University of Cagliari, Italy, Italy
                    1. Paolo Boffetta (boffetta{at}iarc.fr)
                    1. International Agency for Research on Cancer, Lyon, France, France

                      Abstract

                      Background: Conflicting epidemiological evidence exists about an increase in risk of non Hodgkin¡¦s lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCB). Methods: We measured the concentration of 17 OC pesticides, including hexachlorobenzene (HCB), four lindane isomers (ƒÑ-,ƒÒ-,ƒ×-, and ƒÔ-hexachlorocyclohexane (HCH), two chlordane species (heptachlor and oxy-chlordane), four cyclodiene insecticides (Aldrin, Dieldrin, Endrin, and Mirex), and six DDT isomers, and nine PCB congeners, namely congeners 28, 52, 101, 118, 138, 153, 170, 180, and 194, in a plasma sample of 377 subjects, including 174 non Hodgkin¡¦s lymphoma cases and 203 controls from France, Germany, and Spain. Risk of non Hodgkin¡¦s lymphoma and its major subtypes associated with increasing blood level of OC pesticides and PCBs was calculated using unconditional logistic regression. Results: Risk of NHL, diffuse large B cell lymphoma (DLBCL) and chronic lymphatic leukemia (CLL) did not increase with plasma level of HCB, ƒÒ-HCH, p,p¡¦-DDE, total and individual PCB, or their functional groups, in the overall study population. Substantial heterogeneity in DLBCL risk associated with immunotoxic PCBs (p = 0.03) existed between the Spanish subgroup (OR for immunotoxic PCB plasma level above the median vs below the median = 0.7, 95% C.I. 0.3, 1.6) and the French and German subgroups combined (OR = 3.2, 95% C.I. 0.9, 11.5). Conclusion: We did not find evidence of an association between NHL risk and plasma level of OC pesticides and PCBs.

                      • Non Hodgkin lymphoma
                      • chronic lymphatic leukemia
                      • diffuse large B cell lymphoma
                      • organochlorines
                      • polychlorobiphenyls

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