Article Text

other Versions

PDF
External radiation exposure and mortality in a cohort of French nuclear workers
  1. Maylis Telle-Lamberton (maylis.telle-lamberton{at}irsn.fr)
  1. Institut de Radioprotection et de Sûreté Nucléaire, France
    1. Eric Samson (eric.samson{at}irsn.fr)
    1. Institut de Radioprotection et de Sûreté Nucléaire, France
      1. Sylvaine Caër (sylvaine.caer{at}areva.com)
      1. Areva NC, France
        1. Dominique Bergot
        1. Institut de Radioprotection et de Sûreté Nucléaire, France
          1. Denis Bard
          1. Institut de Radioprotection et de Sûreté Nucléaire, France
            1. Francis Bermann
            1. Commissariat à l'Energie Atomique, France
              1. Jean-Marie Gélas
              1. Areva NC, France
                1. Jean-Michel Giraud
                1. Commissariat à l'Energie Atomique, France
                  1. Philippe Hubert
                  1. Institut de Radioprotection et de Sûreté Nucléaire, France
                    1. Camille Metz-Flamant
                    1. Institut de Radioprotection et de Sûreté Nucléaire, France
                      1. Marie-Odile Néron
                      1. Institut de Radioprotection et de Sûreté Nucléaire, France
                        1. Benoit Quesne
                        1. Areva NC, France
                          1. Margot Tirmarche
                          1. Institut de Radioprotection et de Sûreté Nucléaire, France
                            1. Catherine Hill
                            1. Institut Gustave Roussy, France

                              Abstract

                              Objective: To analyze the effect of external radiation exposure on the mortality of French nuclear workers. Methods: A cohort of 29,204 workers employed between 1950 and 1994 at the French Atomic Energy Commission (Commissariat à l’Energie Atomique: CEA) or at the General Company of Nuclear Fuel (COmpagnie GEnérale des MAtières nucléaires: Cogema, now Areva NC) was followed up for an average of 17.8 years. Standardized Mortality Ratios (SMRs) were computed with reference to French mortality rates. Dose-effect relationships were analyzed through trend tests and Poisson regression, with linear and log-linear models. Results: The mean exposure to X and gamma radiation was 8.3 mSv (16.9 mSv for exposed worker population). A total of 1,842 deaths occurred between 1968 and 1994. A Healthy Worker Effect was observed, the number of deaths in the cohort being 59% of the number expected from national mortality statistics. Among the 21 main cancer sites studied, a statistically significant excess was observed only for skin melanoma, and an excess of borderline statistical significance was observed for multiple myeloma. A dose-effect relationship was observed for leukaemia after exclusion of chronic lymphoid leukaemia (CLL). The relative risk observed for non CLL leukaemia, n=20, was 4.1 per 100 mSv, CI90%=[1.4;12.2], linear model and 2.2 per 100 mSv, CI90%=[1.2;3.3], log-linear model. Significant dose-effect relationships were also observed for causes of deaths associated with alcohol consumption: mouth and pharynx cancer, cirrhosis and alcoholic psychosis and external causes of death. Conclusion: The risk of leukaemia increases with increasing exposure to external radiation; this is consistent with published results on other nuclear workers cohorts.

                              • cohort study
                              • ionizing radiation
                              • leukaemia
                              • mortality

                              Statistics from Altmetric.com

                              Request permissions

                              If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.