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Decline in Lung Function and Mortality: Implications for Medical Monitoring
  1. Kanta D Sircar (kanta.sircar{at}gmail.com)
  1. CDC NIOSH, United States
    1. Eva Hnizdo (exh6{at}cdc.gov)
    1. CDC NIOSH, United States
      1. E L Petsonk (elp2{at}cdc.gov)
      1. NIOSH, United States
        1. Michael D Attfield (mda1{at}cdc.gov)
        1. NIOSH, United States

          Abstract

          This study investigated the risk of death associated with selected cutoff points for rate of decline of forced expiratory volume in one second (FEV1). Utilizing a cohort of 1,730 miners who had performed two pulmonary function tests, mortality was follow for an additional 12 years. Based on previous studies, cutoff points for FEV1 rate of decline (mL/yr) were selected as 30, 60 and 90 mL/yr. Cox proportional hazard regression was used to estimate multivariate risk ratio of death in each category. The risk ratios and 95% confidence interval (compared to ‘below 30 mL/yr’) were 1.39 (0.99, 1.97) in the ‘60 to less than 90 mL/yr’ category and 1.90 (1.32, 2.76) in the ‘90 mL/yr and above’ category. Rates of decline above 90 mL/yr were consistently related to excess mortality. In nonsmokers and those with neither restrictive nor obstructive patterns at the first survey, rate of decline above 60 mL/yr were significantly associated with increased mortality. Risk of death increases in individuals with rates of decline above about 60 mL/yr and is statistically significant in declines 90 mL/yr or more. These results should be useful to health care providers in the assessment of lung function declines observed in individuals.

          • Forced Expiratory Volume
          • Longitudinal Studies
          • Lung Function Test
          • Mortality
          • Occupational Health

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