Background Gastro-oesophageal reflux disorder (GERD) has become an important health problem globally in the recent years. Despite known factors of modern lifestyle, habits, old age and obesity, the contribution of work-related factors has been unclear. We aimed to examine work-related factors of erosive oesophagitis (EE).

Methods Currently employed people undergoing physical examination including upper gastrointestinal panendoscopy were recruited from a medical institute in northern Taiwan. EE was diagnosed by panendoscopy, based on the Los Angeles classification. Demographic and work factors were inquired by a self-administered structured questionnaire after informed consent.

Results A total of 636 participants satisfactorily completed the panendoscopy and questionnaire. Among them, 144 (23%) had EE. Work factors associated with EE were long sitting time at work (aOR = 2.66, CI = 1.48–4.94), taking afternoon nap at desk (aOR = 3.52, CI = 2.12–5.90), and “active” job by Job Content Questionnaire (aOR = 2.42, CI = 1.39–4.22), after adjusting for gender, age, body mass index, smoking, and exercise habit. Managerial job was a protective factor for EE (aOR = 0.53, CI = 0.30–0.92).

Conclusions Work-related factors cannot be ignored when managing GERD in employed people.